SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy
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DOI: 10.1371/journal.ppat.1007071
Abstract: HIV-1 Tat is a key regulator of viral transcription, however little is known about the mechanisms that control its turnover in T cells. Here we use a novel proteomics technique, called DiffPOP, to identify the… read more here.
Keywords: deubiquitinase; destruction; brcc36; hiv tat ... See more keywords
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cell"
DOI: 10.2210/pdb6gvw/pdb
Abstract: In mammals, ∼100 deubiquitinases act on ∼20,000 intracellular ubiquitination sites. Deubiquitinases are commonly regarded as constitutively active, with limited regulatory and targeting capacity. The BRCA1-A and BRISC complexes serve in DNA double-strand break repair and… read more here.
Keywords: dna repair; brcc36; repair immune; brca1 ... See more keywords