Recent Advances on Small-Molecule Bromodomain-Containing Histone Acetyltransferase Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01638
Abstract: In recent years, substantial research has been conducted on molecular mechanisms and inhibitors targeting bromodomains (BRDs) and extra-terminal (BET) family proteins. On this basis, non-BET BRD is gradually becoming a research hot spot. BRDs are… read more here.
Keywords: small molecule; brd containing; histone acetyltransferase;
USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy
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DOI: 10.1038/s41598-020-78000-2
Abstract: Bromodomain (BRD)-containing proteins are important for chromatin remodeling to regulate gene expression. In this study, we found that the deubiquitinase USP24 interacted with BRD through its C-terminus increased the levels of most BRD-containing proteins through… read more here.
Keywords: cancer; containing proteins; brd containing; cancer progression ... See more keywords