Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02432-8
Abstract: Genetic studies have repeatedly shown that the Bromodomain containing 1 gene, BRD1, is involved in determining mental health, and the importance of the BRD1 protein for normal brain function has been studied in both cell… read more here.
Keywords: histone acetylation; tail clipping; gene; brain ... See more keywords
BRD1-Mediated Acetylation Promotes Integrin αV Gene Expression Via Interaction with Sulfatide
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DOI: 10.1158/1541-7786.mcr-17-0527
Abstract: Integrin αV gene expression is often dysregulated in cancers especially in hepatocellular carcinoma (HCC); however, the mechanism of regulation is poorly understood. Here, it is demonstrated that sulfatide activated integrin αV gene transcription, through histone… read more here.
Keywords: acetylation; integrin gene; expression; sulfatide ... See more keywords
DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele
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DOI: 10.1371/journal.pone.0170121
Abstract: The bromodomain containing 1 gene, BRD1 is essential for embryogenesis and CNS development. It encodes a protein that participates in histone modifying complexes and thereby regulates the expression of a large number of genes. Genetic… read more here.
Keywords: risk; expression; promoter; dna methylation ... See more keywords