O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.153087
Abstract: Alcoholic liver injury (ALI) is a major risk factor for alcoholic liver disease, characterized by excessive inflammatory response and abnormal liver dysfunction. Previous studies have indicated that O-alkyl and o-benzyl hesperetin derivative-1 L (HD-1 L) has anti-inflammatory… read more here.
Keywords: brd2; alcoholic liver; liver injury; inflammation ... See more keywords
LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1321-5
Abstract: Aberrant expression of laminin-332 promotes tumour growth and metastasis in multiple cancers. However, the dysregulated expression and mechanism of action of LAMB3, which encodes the β3 subunit of laminin-332, and the mechanism underlying dysregulated LAMB3… read more here.
Keywords: foxo3; elk4; brd2; expression ... See more keywords
Spatially restricted loading of BRD2 at DNA double-strand breaks protects H4 acetylation domains and promotes DNA repair
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13036-5
Abstract: The n-terminal tail of histone H4 recruits repair proteins, including 53BP1, to DNA double-strand breaks (DSB) and undergoes dynamic acetylation during DSB repair. However, how H4 acetylation (H4Ac) recruits repair proteins and reorganizes chromatin during… read more here.
Keywords: acetylation; dna; chromatin; brd2 ... See more keywords
The epigenetic reader, BRD2, mediates cholangiocyte senescence via interaction with ETS1.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.03.235
Abstract: BACKGROUND & AIMS We reported that cholangiocyte senescence, regulated by the transcription factor, ETS1, is a pathogenic feature of Primary Sclerosing Cholangitis (PSC). Furthermore, Histone 3 Lysine 27 is acetylated at senescence-associated loci. The epigenetic… read more here.
Keywords: cholangiocyte senescence; bet; senescence; gene expression ... See more keywords
Insights into the crystal structure of BRD2-BD2 – phenanthridinone complex and theoretical studies on phenanthridinone analogs
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1353441
Abstract: Bromodomain and extra-terminal family proteins recognize the acetylated histone code on chromatin and participate in downstream processes like DNA replication, modification, and repair. As part of epigenetic approaches, BRD2 and BRD4 were identified as putative… read more here.
Keywords: crystal structure; brd2 bd2; brd2; phenanthridinone ... See more keywords
DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsia"
DOI: 10.1111/epi.14058
Abstract: Juvenile myoclonic epilepsy (JME) is a common adolescent‐onset genetic generalized epilepsy (GGE) syndrome. Multiple linkage and association studies have found that BRD2 influences the expression of JME. The BRD2‐JME connection is further corroborated by our… read more here.
Keywords: juvenile myoclonic; brd2; myoclonic epilepsy; promoter ... See more keywords