A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Structure"
DOI: 10.1016/j.str.2021.01.010
Abstract: The extraterminal (ET) domain of BRD3 is conserved among BET proteins (BRD2, BRD3, BRD4), interacting with multiple host and viral protein-protein networks. Solution NMR structures of complexes formed between the BRD3 ET domain and either… read more here.
Keywords: host viral; brd3; binding motif; common binding ... See more keywords
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation
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DOI: 10.1038/s41556-020-0572-2
Abstract: Cooperation between DNA, RNA and protein regulates gene expression and controls differentiation through interactions that connect regions of nucleic acids and protein domains and through the assembly of biomolecular condensates. Here, we report that endoderm… read more here.
Keywords: protein; endoderm differentiation; brd3; differentiation ... See more keywords
Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis
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DOI: 10.1126/sciadv.ade3422
Abstract: Metastasis is the main cause of death in many cancers including colorectal cancer (CRC); however, the underlying mechanisms responsible for metastatic progression remain largely unknown. We found that nuclear TYRO3 receptor tyrosine kinase is a… read more here.
Keywords: metastasis; brd3; nuclear tyro3; tyro3 ... See more keywords
Abstract 3931: BRD4, BRD3, NSD3, and ZNF532 fusions in histologies beyond NUT carcinomas: Investigation of a large pan-cancer cohort
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DOI: 10.1158/1538-7445.am2023-3931
Abstract: Background: NUT rearrangements drive NUT carcinomas (NCs), which are rare, poorly differentiated tumors with a survival from diagnosis of ~6-7 months. Common NUT fusion partners (NCFPs) include BRD4, BRD3, NSD3, and ZNF532, which are associated… read more here.
Keywords: nsd3 znf532; brd3; brd4 brd3; znf532 ... See more keywords