Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance
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DOI: 10.1038/s41467-019-14083-4
Abstract: BET bromodomain inhibitors (BETi), such as JQ1, have been demonstrated to effectively kill multiple types of cancer cells. However, the underlying mechanisms for BETi resistance remain largely unknown. Our evidences show that JQ1 treatment evicts… read more here.
Keywords: jund; mir 548d; brd4 foxd3; resistance ... See more keywords