CXCL6‐EGFR‐induced Kupffer cells secrete TGF‐β1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C‐MYC/EZH2 pathway in liver fibrosis
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DOI: 10.1111/jcmm.13787
Abstract: Liver fibrosis is the excessive accumulation of extracellular matrix proteins in response to the inflammatory response that accompanies tissue injury, which at an advanced stage can lead to cirrhosis and even liver failure. This study… read more here.
Keywords: cxcl6; fibrosis; liver fibrosis; tgf ... See more keywords
BRD4 and MYC—clarifying regulatory specificity
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aat6664
Abstract: A study dissects the primary function of cancer-associated transcription factors The transcriptional output of cells is governed by the interplay among sequence-specific transcription factors (TFs), epigenetic DNA and chromatin modifications, and their writers, readers, and… read more here.
Keywords: myc clarifying; regulatory specificity; brd4; brd4 myc ... See more keywords