BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma
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DOI: 10.1158/1078-0432.ccr-22-3668
Abstract: Abstract Purpose: BRD9 is a defining component of the noncanonical SWI/SNF complex, which regulates gene expression by controlling chromatin dynamics. Although recent studies have found an oncogenic role for BRD9 in multiple cancer types including… read more here.
Keywords: ribosome biogenesis; myeloma; expression; brd9 ... See more keywords
Abstract B14: A novel role for BRD9 in regulating cellular growth and DNA damage response pathways
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DOI: 10.1158/1557-3125.dnarepair16-b14
Abstract: Bromodomain containing protein BRD9 has been identified as a component of the SWI/SNF chromatin remodeling complex. Next generation sequencing studies have revealed that SWI/SNF is the most highly perturbed chromatin remodeling complex in cancer with… read more here.
Keywords: swi snf; role brd9; brd9; damage ... See more keywords
Bromodomain-containing protein 9 activates proliferation and epithelial-mesenchymal transition of colorectal cancer via the estrogen pathway in vivo and in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-23-271
Abstract: Background Bromodomain-containing protein 9 (BRD9) has been reported to be upregulated in multiple malignancies and facilitate cancer progression. However, there is a paucity of data relating to its expression and biological role in colorectal cancer… read more here.
Keywords: expression; crc; brd9; estrogen pathway ... See more keywords
Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer
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DOI: 10.3390/biom11121794
Abstract: Background and aims: Despite recent advances in advanced prostate cancer treatments, clinical biomarkers or treatments for men with such cancers are imperfect. Targeted therapies have shown promise, but there remain fewer actionable targets in prostate… read more here.
Keywords: cancer; brd9; prostate cancer; therapeutic target ... See more keywords
Deciphering Selectivity Mechanism of BRD9 and TAF1(2) toward Inhibitors Based on Multiple Short Molecular Dynamics Simulations and MM-GBSA Calculations
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DOI: 10.3390/molecules28062583
Abstract: BRD9 and TAF1(2) have been regarded as significant targets of drug design for clinically treating acute myeloid leukemia, malignancies, and inflammatory diseases. In this study, multiple short molecular dynamics simulations combined with the molecular mechanics… read more here.
Keywords: taf1; brd9 taf1; brd9; short molecular ... See more keywords