BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-024-01306-5
Abstract: Bromodomain containing protein 9 (BRD9), a member of the non-canonical BRG1/BRM-associated factor (ncBAF) chromatin remodeling complex, has been implicated as a synthetic lethal target in AML but its function in normal human hematopoiesis is unknown.… read more here.
Keywords: differentiation; hematopoietic stem; lineage; brd9 ... See more keywords
Integrative analysis reveals synergistic regulation of Sp7 by BRD9 and Wnt/β-catenin signaling during osteogenic differentiation.
Sign Up to like & getrecommendations! Published in 2025 at "Communications biology"
DOI: 10.1038/s42003-025-09278-z
Abstract: Osteoporosis is a complex skeletal disorder characterized by low bone mineral density (BMD). Compared with classical epigenetic modifications, such as DNA methylation and histone modifications, the participation of chromatin-remodeling complexes in osteoporosis remains less explored.… read more here.
Keywords: differentiation; analysis; catenin signaling; wnt catenin ... See more keywords
BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-22-3668
Abstract: Abstract Purpose: BRD9 is a defining component of the noncanonical SWI/SNF complex, which regulates gene expression by controlling chromatin dynamics. Although recent studies have found an oncogenic role for BRD9 in multiple cancer types including… read more here.
Keywords: ribosome biogenesis; myeloma; expression; brd9 ... See more keywords
Abstract 6046: CFT8634, a BRD9 BiDAC™ degrader, is active in a subset of multiple myeloma cell line models and synergistic when combined with pomalidomide or dexamethasone
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-6046
Abstract: Recent literature has shown that loss-of-function of BRD9, a component of the noncanonical SWI/SNF (ncSWI/SNF) complex, mediated by RNA interference or by BRD9 degrader compounds can inhibit multiple myeloma (MM) cell lines and primary MM… read more here.
Keywords: multiple myeloma; degrader; cell; brd9 ... See more keywords
Abstract B14: A novel role for BRD9 in regulating cellular growth and DNA damage response pathways
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.dnarepair16-b14
Abstract: Bromodomain containing protein BRD9 has been identified as a component of the SWI/SNF chromatin remodeling complex. Next generation sequencing studies have revealed that SWI/SNF is the most highly perturbed chromatin remodeling complex in cancer with… read more here.
Keywords: swi snf; role brd9; brd9; damage ... See more keywords
Targeting BRD9 in KMT2A-rearranged Acute Myeloid Leukemia to circumvent MEN1 inhibitor resistance
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-1463
Abstract: Introduction: Acute myeloid leukemia (AML) with rearrangement of the KMT2A gene (KMT2Ar) is a blood malignancy with adverse clinical outcome. Many of these patients develop resistance to chemotherapies and are not eligible for stem cell… read more here.
Keywords: men1; aml; cell; expression ... See more keywords
BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer"
DOI: 10.1186/s12943-025-02449-w
Abstract: BRD9 is involved in multiple physiological and pathological pathways, yet its functional role and molecular mechanisms in gastric cancer (GC) remain largely unexplored. Addressing this knowledge gap is critical given the persistent global mortality burden… read more here.
Keywords: brd9; dna damage; damage repair; gastric cancer ... See more keywords
Bromodomain-containing protein 9 activates proliferation and epithelial-mesenchymal transition of colorectal cancer via the estrogen pathway in vivo and in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-23-271
Abstract: Background Bromodomain-containing protein 9 (BRD9) has been reported to be upregulated in multiple malignancies and facilitate cancer progression. However, there is a paucity of data relating to its expression and biological role in colorectal cancer… read more here.
Keywords: expression; crc; brd9; estrogen pathway ... See more keywords
Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11121794
Abstract: Background and aims: Despite recent advances in advanced prostate cancer treatments, clinical biomarkers or treatments for men with such cancers are imperfect. Targeted therapies have shown promise, but there remain fewer actionable targets in prostate… read more here.
Keywords: cancer; brd9; prostate cancer; therapeutic target ... See more keywords
Deciphering Selectivity Mechanism of BRD9 and TAF1(2) toward Inhibitors Based on Multiple Short Molecular Dynamics Simulations and MM-GBSA Calculations
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062583
Abstract: BRD9 and TAF1(2) have been regarded as significant targets of drug design for clinically treating acute myeloid leukemia, malignancies, and inflammatory diseases. In this study, multiple short molecular dynamics simulations combined with the molecular mechanics… read more here.
Keywords: taf1; brd9 taf1; brd9; short molecular ... See more keywords
Identification and Development of BRD9 Chemical Probes
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceuticals"
DOI: 10.3390/ph17030392
Abstract: The development of BRD9 inhibitors involves the design and synthesis of molecules that can specifically bind the BRD9 protein, interfering with the function of the chromatin-remodeling complex ncBAF, with the main advantage of modulating gene… read more here.
Keywords: brd9 chemical; chemical probes; development brd9; identification development ... See more keywords