The effect of EML4-ALK break-apart ratio on crizotinib outcomes in non-small cell lung cancer harboring EML4-ALK rearrangement
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03546-1
Abstract: Anaplastic lymphoma kinase (ALK) gene rearrangement exists in approximately 3–7% of non-small cell lung cancer (NSCLC) and more than 15% split or isolated red signals among 50 tumor nuclei scored in the FISH analysis defines… read more here.
Keywords: alk; alk rearrangement; break apart; alk positive ... See more keywords
SS18 Break-Apart Fluorescence In Situ Hybridization is a Practical and Effective Method for Diagnosing Microsecretory Adenocarcinoma of Salivary Glands
Sign Up to like & getrecommendations! Published in 2021 at "Head and Neck Pathology"
DOI: 10.1007/s12105-020-01280-7
Abstract: Molecular analysis has allowed for refinement of salivary gland tumor classification and, in some cases, the recognition of entirely new tumor types. Microsecretory adenocarcinoma (MSA) is a salivary gland tumor described in 2019 characterized by… read more here.
Keywords: break apart; pathology; apart fish; carcinomas ... See more keywords
Clonal haematopoiesis of indeterminate potential among cancer survivors exposed to myelotoxic chemotherapy
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DOI: 10.1111/bjh.15861
Abstract: genetic subtype. Fig S1. (A) Bacterial artificial chromosome (BACs) used for fluorescence in situ hybridization DUSP22 break-apart assays with hg 19 co-ordinates. (B) Partial karyotype showing the expected site of chromosomal localization (6p25.3) on normal… read more here.
Keywords: clonal haematopoiesis; negative neg; alk; break apart ... See more keywords
False positivity in break apart fluorescence in-situ hybridization due to polyploidy
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DOI: 10.21037/tlcr-22-516
Abstract: Background In-situ hybridization (ISH) is a diagnostic tool in the detection of chromosomal anomalies, which has important implications for diagnosis, classification and prediction of cancer therapy in various diseases. Certain thresholds of number of cells… read more here.
Keywords: lung cancer; situ hybridization; polyploidy; break apart ... See more keywords