DNA Double-Strand Break-Induced Gene Amplification in Yeast.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0644-5_17
Abstract: Precise control of the gene copy number in the model yeast Saccharomyces cerevisiae may facilitate elucidation of enzyme functions or, in cell factory design, can be used to optimize production of proteins and metabolites. Currently,… read more here.
Keywords: induced gene; dna double; strand break; double strand ... See more keywords
DNA Polymerase Delta Synthesizes Both Strands during Break-Induced Replication.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.07.033
Abstract: Break-induced replication (BIR) is a pathway of homology-directed repair that repairs one-ended DNA breaks, such as those formed at broken replication forks or uncapped telomeres. In contrast to conventional S phase DNA synthesis, BIR proceeds… read more here.
Keywords: dna; dna polymerase; break induced; replication ... See more keywords
Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01987-2
Abstract: Break-induced replication (BIR) is a DNA double-strand break repair pathway that leads to genomic instabilities similar to those observed in cancer. BIR proceeds by a migrating bubble where asynchrony between leading and lagging strand synthesis… read more here.
Keywords: promotes formation; joint molecules; break induced; break ... See more keywords
Cell wall protein variation, break‐induced replication, and subtelomere dynamics in Candida glabrata
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Microbiology"
DOI: 10.1111/mmi.14707
Abstract: Candida glabrata is an opportunistic pathogen of humans, responsible for up to 30% of disseminated candidiasis. Adherence of C. glabrata to host cells is mediated by adhesin‐like proteins (ALPs), about half of which are encoded… read more here.
Keywords: variation; break induced; candida glabrata; induced replication ... See more keywords
Repair of DNA Breaks by Break-Induced Replication.
Sign Up to like & getrecommendations! Published in 2021 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-081420-095551
Abstract: Double-strand DNA breaks (DSBs) are the most lethal type of DNA damage, making DSB repair critical for cell survival. However, some DSB repair pathways are mutagenic and promote genome rearrangements, leading to genome destabilization. One… read more here.
Keywords: biochemistry; dna breaks; break induced; repair ... See more keywords
Suppressors of Break-Induced Replication in Human Cells
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14020398
Abstract: Short tandem DNA repeats are drivers of genome instability. To identify suppressors of break-induced mutagenesis human cells, unbiased genetic screens were conducted using a lentiviral shRNA library. The recipient cells possessed fragile non-B DNA that… read more here.
Keywords: break induced; dna; suppressors break; human cells ... See more keywords