The role of double‐strand break repair, translesion synthesis, and interstrand crosslinks in colorectal cancer progression—clinicopathological data and survival
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.25737
Abstract: DNA repair is a new and important pathway that explains colorectal carcinogenesis. This study will evaluate the prognostic value of molecular modulation of double‐strand break repair (XRCC2 and XRCC5); DNA damage tolerance/translesion synthesis (POLH, POLK,… read more here.
Keywords: break repair; colorectal cancer; translesion synthesis; strand break ... See more keywords
Transcriptionally tailored break repair
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0069-z
Abstract: DNA double-strand breaks at active genes are repaired by a dedicated homologous recombination mechanism involving R-loop formation and RAD52 recruitment. read more here.
Keywords: transcriptionally tailored; break repair; biology; tailored break ... See more keywords
The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208904119
Abstract: Significance Here, we report that the lncRNA MILIP is transcriptionally regulated by N-Myc and functions to promote DNA double-strand break repair in neuroblastoma cells. MILIP is distinguished from other lncRNAs implicated in DNA repair through… read more here.
Keywords: break repair; dna double; double strand; strand break ... See more keywords
APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrad007
Abstract: Abstract Aprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA… read more here.
Keywords: aptx; xrcc4; strand break; break repair ... See more keywords
A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins
Sign Up to like & getrecommendations! Published in 2018 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672918050010
Abstract: Poly(ADP-ribosyl)ation, which is catalyzed by PARP family proteins, is one of the main reactions in the cell response to genomic DNA damage. Massive impact of DNA-damaging agents (such as oxidative stress and ionizing radiation) causes… read more here.
Keywords: break repair; base excision; dna; excision repair ... See more keywords
Abstract 2823: DNA methyltransferase inhibitors sensitize NSCLC cells to PARP inhibitors by induction of a double strand break repair defect
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2823
Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the US. Poly (ADP-ribose) polymerase inhibitors (PARPi) show efficacy as radiosensitizers in NSCLC, but arguably have gained greater importance in cancer therapeutics… read more here.
Keywords: break repair; dna; strand break; double strand ... See more keywords
Does single strand DNA break repair capacity influence oocyte maintenance and quality?
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-22-0325
Abstract: Human genome-wide association studies and evidence from animal models link ovarian ageing to double-stranded (ds) DNA break repair capacity. Is there a connection between single-stranded (ss)DNA repair mechanisms and ovarian function? We hypothesize that endogenous… read more here.
Keywords: dna break; repair capacity; break repair; repair ... See more keywords
Ubiquitylation-Mediated Fine-Tuning of DNA Double-Strand Break Repair
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12061617
Abstract: The proper function of DNA repair is indispensable for eukaryotic cells since accumulation of DNA damages leads to genome instability and is a major cause of oncogenesis. Ubiquitylation and deubiquitylation play a pivotal role in… read more here.
Keywords: break repair; dna; dna double; strand break ... See more keywords
DNA double-strand break repair and nucleic acid-related immunity
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022061
Abstract: DNA damage repair and innate immunity are two conserved mechanisms that both function in cellular stress responses. Recently, an increasing amount of evidence has uncovered the close relationship between these two ancient biological processes. Here,… read more here.
Keywords: break repair; immunity; innate immunity; double strand ... See more keywords