Bond-Breaking Bio-orthogonal Chemistry Efficiently Uncages Fluorescent and Therapeutic Compounds under Physiological Conditions.
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DOI: 10.1021/acs.orglett.0c02129
Abstract: Bond-breaking bio-orthogonal chemistry, consisting of a "click" reaction between trans-cyclooctene and tetrazine, followed by an intramolecular cyclization-driven uncaging step is described. The two-step process allows activation of caged compounds in biological media at neutral pH.… read more here.
Keywords: bond breaking; bio orthogonal; chemistry; orthogonal chemistry ... See more keywords