Breakthrough invasive fungal diseases during voriconazole treatment for aspergillosis: A 5-year retrospective cohort study
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DOI: 10.1093/mmy/myw067
Abstract: Abstract Breakthrough invasive fungal diseases (bIFDs) during voriconazole treatment are concerning, as they are associated with high rates of mortality and pathogen distribution. To evaluate the prevalence, incidence, patient characteristics, including IFD events, and overall… read more here.
Keywords: voriconazole treatment; breakthrough invasive; fungal diseases; treatment ... See more keywords
1301. Breakthrough Invasive Fungal Infections based on CYP2C19 Levels in Patients Who were on Voriconazole as Primary Antifungal Prophylaxis in Acute Myeloid Leukemia (AML) undergoing Induction Chemotherapy
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DOI: 10.1093/ofid/ofaa439.1484
Abstract: Voriconazole (Vori) is often used for prophylactic anti-fungal therapy in induction chemotherapy for Acute Myeloid Leukemia (AML) patients due to predictable absorption and an extended spectrum antifungal activity. Vori is metabolized predominately by CYP2C19 to… read more here.
Keywords: breakthrough invasive; fungal infections; invasive fungal; induction ... See more keywords
Breakthrough Invasive Fungal Infection After Coadministration of Venetoclax and Voriconazole
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DOI: 10.1093/ofid/ofad134
Abstract: Abstract Venetoclax requires a 75% dose reduction when coadministered with voriconazole. In a 10-year historical cohort of treatment with venetoclax, we did not observe a worse hematologic outcome in patients who received voriconazole prophylaxis versus… read more here.
Keywords: invasive fungal; infection coadministration; breakthrough invasive; coadministration venetoclax ... See more keywords
Breakthrough Invasive Candidiasis in Children
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DOI: 10.1093/ofid/ofx163.024
Abstract: Abstract Background Breakthrough invasive candidiasis (bIC) has been described in adults, but the epidemiology and outcomes in children are unknown. Methods Retrospective cohort analysis of children diagnosed with IC from 9/1/09 to 1/30/17. bIC was… read more here.
Keywords: invasive candidiasis; breakthrough invasive; bic; epidemiology ... See more keywords