Targeting of ΔNp63α by miR‐522 promotes the migration of breast epithelial cells
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13072
Abstract: The TP63 gene, which encodes the p63 protein, is involved in multiple biological processes, including embryonic development and tumorigenesis. ΔNp63α, the predominant isoform of p63 in epithelial cells, acts as an oncogene in early‐stage tumors,… read more here.
Keywords: epithelial cells; breast epithelial; mir; targeting np63 ... See more keywords
CCL20 promotes migration and invasiveness of human cancerous breast epithelial cells in primary culture
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22693
Abstract: The relation between the tumor and its microenvironment is one of the most interesting and less understood issues. Recently, we showed a role of CCL20 chemokine in proning the healthy tissue neighboring the tumor to… read more here.
Keywords: epithelial cells; ccl20; breast epithelial; migration ... See more keywords
Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.03.019
Abstract: Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited.… read more here.
Keywords: mesenchymal transition; epithelial cell; breast epithelial; metabolic wiring ... See more keywords
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04334-1
Abstract: Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of heterogeneity and differentiation… read more here.
Keywords: single cell; human breast; epithelial cells; breast ... See more keywords
Leptin Mediates Obesity-Induced DNA Damage in BRCA1 Breast Epithelial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvab048.2095
Abstract: Background: Obesity is a risk factor for breast cancer development in women who carry a mutation in the DNA repair enzymes BRCA1 or BRCA2. Previously, we found that obesity was positively associated with DNA damage… read more here.
Keywords: breast epithelial; damage; dna damage; epithelial cells ... See more keywords
Baicalein has protective effects on the 17β-estradiol-induced transformation of breast epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14433
Abstract: Epidemiologic and systematic studies have indicated that flavonoid consumption is associated with a lower incidence of breast cancer. Baicalein is the primary flavonoid derived from the roots of Scutellaria baicalensis Georgi. In the current study,… read more here.
Keywords: epithelial cells; baicalein protective; breast; breast epithelial ... See more keywords
Chronic Exposure to Nitric Oxide Induces P53 Mutations and Malignant-like Features in Human Breast Epithelial Cells
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020311
Abstract: The small endogenous signaling molecule nitric oxide (NO) has been linked with chronic inflammation and cancer. The effects of NO are both concentration and temporally dependent; under some conditions, NO protects against damage caused by… read more here.
Keywords: nitric oxide; breast epithelial; chronic exposure; epithelial cells ... See more keywords
Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071707
Abstract: Simple Summary The recent discovery of the genetic identity of the tubulin carboxypeptidase (TCP) provides a unique opportunity to study the role of the detyrosination of α-tubulin (deTyr-Tub), as performed by the TCP, in breast… read more here.
Keywords: focal gelatin; breast cancer; breast epithelial; detyr tub ... See more keywords