Assessing Breast and Ovarian Cancer Risk Prior to Gender-Affirming Surgery.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA surgery"
DOI: 10.1001/jamasurg.2022.5447
Abstract: This Viewpoint discusses the need for assessing the risk of hereditary breast and ovarian cancer in individuals seeking gender-affirming surgery and referring eligible patients to genetic counseling and testing services before surgery. read more here.
Keywords: surgery; breast ovarian; ovarian cancer; risk ... See more keywords
“There's not enough studies”: Views of black breast and ovarian cancer patients on research participation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5622
Abstract: Black breast and ovarian cancer patients are underrepresented in clinical cancer trials disproportionate to the prevalence of these cancers in Black females. Historically, lower enrollment has been attributed to individualized factors, including medical mistrust, but… read more here.
Keywords: ovarian cancer; breast ovarian; cancer patients; black breast ... See more keywords
The role of menopausal hormone therapy in women with or at risk of ovarian and breast cancers: Misconceptions and current directions
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.31911
Abstract: For women who are candidates for menopausal hormone therapy (MHT), estrogen can provide relief from symptomatic menopause, decrease rates of chronic illnesses, and improve health‐related quality of life. However, confusion surrounds the evidence regarding the… read more here.
Keywords: therapy; risk; breast; breast ovarian ... See more keywords
Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30428
Abstract: Breast and ovarian cancer (BC/OC) predisposition has been attributed to a number of high‐ and moderate to low‐penetrance susceptibility genes. With the advent of next generation sequencing (NGS) simultaneous testing of these genes has become… read more here.
Keywords: panel; breast ovarian; ovarian cancer; cancer ... See more keywords
Recurrent moderate‐risk mutations in Finnish breast and ovarian cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32309
Abstract: Mutations in BRCA1 and BRCA2 genes predispose to breast and ovarian cancer (BC/OC) with a high lifetime risk, whereas mutations in PALB2, CHEK2, ATM, FANCM, RAD51C and RAD51D genes cause a moderately elevated risk. In… read more here.
Keywords: risk; breast ovarian; ovarian cancer; recurrent moderate ... See more keywords
A dominant RAD51C pathogenic splicing variant predisposes to breast and ovarian cancer in the Newfoundland population due to founder effect
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1070
Abstract: RAD51C is important in DNA repair and individuals with pathogenic RAD51C variants have increased risk of hereditary breast and ovarian cancer syndrome (HBOC), an autosomal dominant genetic predisposition to early onset breast and/or ovarian cancer. read more here.
Keywords: rad51c pathogenic; breast ovarian; ovarian cancer; dominant rad51c ... See more keywords
Multigene panel testing for hereditary breast and ovarian cancer in the province of Ontario
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03377-6
Abstract: Purpose The aim of this study was to determine the diagnostic yield of multigene panel testing among patients referred with hereditary breast and ovarian cancer (HBOC). Methods Patients who met provincial eligibility criteria were tested… read more here.
Keywords: multigene panel; breast ovarian; panel testing; cancer ... See more keywords
Inherited predisposition to breast and ovarian cancer in non-Jewish populations in Israel
Sign Up to like & getrecommendations! Published in 2017 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-017-4474-3
Abstract: PurposeThe contribution of genetic factors to cancer in non-Jewish populations in Israel is understudied. Yet the early, mostly premenopausal age at breast cancer diagnosis is suggestive of an inherited predisposition.MethodsHigh-risk cancer cases of non-Jewish origin… read more here.
Keywords: breast; predisposition; breast ovarian; ovarian cancer ... See more keywords
Impact of Panel Gene Testing for Hereditary Breast and Ovarian Cancer on Patients
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DOI: 10.1007/s10897-017-0090-y
Abstract: Recent advances in next generation sequencing have enabled panel gene testing, or simultaneous testing for mutations in multiple genes for a clinical condition. With more extensive and widespread genetic testing, there will be increased detection… read more here.
Keywords: cancer; panel gene; breast ovarian; ovarian cancer ... See more keywords
Frequency of mutations in BRCA genes and other candidate genes in high-risk probands or probands with breast or ovarian cancer in the Czech Republic
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05378-7
Abstract: Breast cancer is currently the most common form of malignant tumour in womenboth in the Czech Republic and in most countries of the western world, and its incidence is constantly increasing. Many risk factors are… read more here.
Keywords: high risk; breast ovarian; ovarian cancer; czech republic ... See more keywords
Utility of a mainstreamed genetic testing pathway in breast and ovarian cancer patients during the COVID-19 pandemic
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Medical Genetics"
DOI: 10.1016/j.ejmg.2020.104098
Abstract: Introduction Mainstreamed genetic testing (MGT) obviates the need for a cancer genetics consultation, since trained oncologists (O) and gynaecologists (G) provide counseling, prescribe testing and deliver results. We report results from our MGT program and… read more here.
Keywords: genetic testing; genetics; pathway breast; breast ovarian ... See more keywords