MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.193
Abstract: Gene expression analysis of The Cancer Genome Atlas (TCGA) breast cancer data set show that miR-20a is upregulated in human breast cancer, especially in triple-negative subtype. Gene Set Enrichment Analysis suggests that miR-20a expression negatively… read more here.
Keywords: mir 20a; breast cancer; breast tumorigenesis; 20a mediated ... See more keywords
PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aaz0356
Abstract: PHF20L1, a H3K27me2 reader, promotes breast tumorigenesis by cooperating with the PRC2/NuRD complex. TUDOR domain–containing proteins (TDRDs) are chiefly responsible for recognizing methyl-lysine/arginine residue. However, how TDRD dysregulation contributes to breast tumorigenesis is poorly understood.… read more here.
Keywords: phf20l1 h3k27me2; tumorigenesis; breast tumorigenesis; h3k27me2 reader ... See more keywords
HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-1533
Abstract: Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification of MED1 and HER2… read more here.
Keywords: tumorigenesis; her2 driven; med1; breast tumorigenesis ... See more keywords
VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
Sign Up to like & getrecommendations! Published in 2018 at "BMC Biology"
DOI: 10.1186/s12915-018-0576-6
Abstract: BackgroundThe WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α.ResultsTo better understand the involvement… read more here.
Keywords: tumor suppressor; breast tumorigenesis; vopp1; wwox ... See more keywords
CCL2-Mediated Stromal Interactions Drive Macrophage Polarization to Increase Breast Tumorigenesis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087385
Abstract: CCL2 is an inflammatory cytokine that regulates macrophage activity and is implicated in increased mammographic density and early breast tumorigenesis. The role of CCL2 in mediating stromal interactions that contribute to breast tumorigenesis has yet… read more here.
Keywords: tumorigenesis; ccl2; stromal interactions; macrophage ... See more keywords