c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses
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DOI: 10.1038/s41392-022-00948-6
Abstract: B cells secreting IL-10 functionally are recognized as functional regulatory B (Breg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting Breg cells in humans is still lacking. Here,… read more here.
Keywords: inflammatory; functional breg; breg; functional regulatory ... See more keywords
Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis.
Sign Up to like & getrecommendations! Published in 2019 at "Rheumatology"
DOI: 10.1093/rheumatology/kez204
Abstract: OBJECTIVES Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL-10 (B10 cells), a critical anti-inflammatory B-cell subset, were found to be decreased in both… read more here.
Keywords: breg cells; psoriatic arthritis; apremilast; psa psoriasis ... See more keywords
IMBALANCE FAVOURING FOLLICULAR HELPER T CELLS OVER IL10+ REGULATORY B CELLS IS DETRIMENTAL FOR THE RENAL ALLOGRAFT
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation"
DOI: 10.1097/01.tp.0000698924.07922.54
Abstract: Background: A high frequency of regulatory B (Breg) cells, generally transitional B cells (Btrans), has been associated with long-term kidney allograft survival and operational tolerance, while circulating follicular helper T cells (cTfh) correlate with graft… read more here.
Keywords: breg cells; graft; breg; follicular helper ... See more keywords
Frequency and immunophenotype of IL10‐producing regulatory B cells in optic neuritis
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1111/imm.13024
Abstract: Mouse models of multiple sclerosis (MS) have shown the importance of interleukin‐10 (IL‐10) ‐producing regulatory B (Breg) cells in dampening disease activity and inhibiting disease initiation and progression. In MS and other autoimmune diseases decreased… read more here.
Keywords: breg cells; frequency; disease; optic neuritis ... See more keywords
Regulatory B cells protect against chronic hypoxia‐induced pulmonary hypertension by modulating the Tfh/Tfr immune balance
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DOI: 10.1111/imm.13589
Abstract: Hypoxia‐induced pulmonary hypertension (HPH) is a progressive and lethal disease characterized by the uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) and obstructive vascular remodelling. Previous research demonstrated that Breg cells were involved in… read more here.
Keywords: pulmonary hypertension; chronic hypoxia; hypoxia; breg cells ... See more keywords
The Regulation between CD4+CXCR5+ Follicular Helper T (Tfh) Cells and CD19+CD24hiCD38hi Regulatory B (Breg) Cells in Gastric Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/9003902
Abstract: Purpose T follicular helper (Tfh) cells and regulatory B (Breg) cells are reported to play essential roles in humoral immunity, especially in inflammation, autoimmune diseases, and cancer. Hence, we sought to investigate the involvement of… read more here.
Keywords: breg; tfh cells; gastric cancer; breg cells ... See more keywords
Regulatory B Cells and Its Role in Central Nervous System Inflammatory Demyelinating Diseases
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DOI: 10.3389/fimmu.2020.01884
Abstract: Regulatory B (Breg) cells represent a population of suppressor B cells that participate in immunomodulatory processes and inhibition of excessive inflammation. The regulatory function of Breg cells have been demonstrated in mice and human with… read more here.
Keywords: breg cells; nervous system; central nervous; regulatory cells ... See more keywords
Inhibition of Glycogen Synthase Kinase 3β Increases the Proportion and Suppressive Function of CD19+CD24hiCD27+ Breg Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.603288
Abstract: CD19+CD24hiCD27+ memory Breg cells exhibit decreased abundance in patients with chronic graft-versus-host disease (cGVHD) after liver transplantation and produce less IL-10 than those from patients without cGVHD and healthy donors. Due to the lack of… read more here.
Keywords: breg cells; kinase; proportion; mbreg cells ... See more keywords
The Multiple Roles of B Cells in the Pathogenesis of Sjögren’s Syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.684999
Abstract: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration and tissue destruction of exocrine glands such as salivary glands. Although the formation of ectopic lymphoid tissue in exocrine glands and overproduction… read more here.
Keywords: breg cells; gren syndrome; cell subsets; tissue ... See more keywords
Editorial: The Spectrum of Lymphoid Subsets in Allergic Diseases: Immune Regulation and Immunotherapy
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DOI: 10.3389/fimmu.2022.869781
Abstract: Allergic diseases, including allergic rhinitis (AR), asthma, anaphylaxis, food allergies, atopic dermatitis (AD), and drug allergies, are a group of disorders caused by hypersensitivity of the immune system to innocuous environmental antigens (1). These diseases… read more here.
Keywords: breg cells; spectrum lymphoid; allergic diseases; subsets allergic ... See more keywords
Unraveling the role of Breg cells in digestive tract cancer and infectious immunity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.981847
Abstract: Over the past two decades, regulatory B cells (Breg cells or Bregs) have emerged as an immunosuppressive subset of B lymphocytes playing a key role in inflammation, infection, allergy, transplantation, and cancer. However, the involvement… read more here.
Keywords: role; tract; digestive tract; cells digestive ... See more keywords