Population Pharmacokinetics of Oral Brepocitinib in Healthy Volunteers and Patients
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DOI: 10.1002/cpdd.1163
Abstract: Brepocitinib is a tyrosine kinase 2 and Janus kinase 1 inhibitor in development for treatment of inflammatory autoimmune diseases. This analysis aimed to add to the pharmacokinetic knowledge of the medication, through development of a… read more here.
Keywords: volunteers patients; healthy volunteers; brepocitinib; model ... See more keywords
A phase 1 study to investigate the absorption, distribution, metabolism and excretion of brepocitinib in healthy males using a 14 C-microdose approach.
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DOI: 10.1111/bcp.15786
Abstract: AIMS Brepocitinib is a tyrosine kinase 2/Janus kinase 1 inhibitor being investigated for the treatment of several autoimmune diseases. This study assessed the absorption, distribution, metabolism and excretion of oral brepocitinib, and the absolute oral… read more here.
Keywords: period; brepocitinib; dose; absorption distribution ... See more keywords
How will brepocitinib cream compare with established treatments for mild‐to‐moderate eczema?
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DOI: 10.1111/bjd.21880
Abstract: Brepocitinib (PF-06700841) is a small-molecule dual inhibitor of tyrosine kinase 2 and Janus kinase (JAK)1 previously administered orally in trials of other inflammatory dermatoses. In this issue of the BJD, Landis and coauthors report the… read more here.
Keywords: mild moderate; brepocitinib; brepocitinib cream; moderate eczema ... See more keywords
Characterizing the relationships between patient‐reported outcomes and clinician assessments of alopecia areata in a phase 2a randomized trial of ritlecitinib and brepocitinib
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DOI: 10.1111/jdv.17909
Abstract: The phase 2a ALLEGRO trial (NCT02974868) investigated the safety and efficacy of ritlecitinib (PF‐06651600) and brepocitinib (PF‐06700841) in adults with alopecia areata. No randomized controlled trial for alopecia areata has evaluated correlations between clinician‐assessed hair… read more here.
Keywords: reported outcomes; brepocitinib; patient reported; trial ... See more keywords