Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown—a model of mania
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4543-7
Abstract: RationaleBipolar disorder (BD) is a unique mood disorder defined by periods of depression and mania. The defining diagnosis of BD is the presence of mania/hypomania, with symptoms including hyperactivity and risk-taking. Since current treatments do… read more here.
Keywords: risk; brexpiprazole; model; mice ... See more keywords
Do cariprazine and brexpiprazole cause impulse control symptoms? A case/non-case study
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.05.001
Abstract: Aripiprazole has been associated with impulse control symptoms (ICS). Recently, two drugs with similar pharmacological features have become available: cariprazine and brexpiprazole. All of them interact with the D3 receptor, which plays a role in… read more here.
Keywords: impulse control; cariprazine brexpiprazole; study; case ... See more keywords
Brexpiprazole for treatment-resistant major depressive disorder
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DOI: 10.1080/14656566.2019.1654457
Abstract: ABSTRACT Introduction:Treatment-resistant depression (TRD), seldom interchangeably referred to as ‘depression inadequately responding to the standard antidepressant drug,’ carries a significant burden. The atypical antipsychotics represent a popular augmentation strategy for antidepressant-resistant depression, although their efficacy/safety… read more here.
Keywords: treatment resistant; depressive disorder; treatment; major depressive ... See more keywords
Stability Indicating TLC Method for Quantification of Brexpiprazole in Bulk and Its Pharmaceutical Dosage Form and Determination of Content Uniformity.
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DOI: 10.1093/chromsci/bmz039
Abstract: A sensitive, selective and precise high performance thin layer chromatographic method has been developed and validated for the quantification of Brexpiprazole in bulk drug and in pharmaceutical dosage form. The method employed HPTLC aluminum plates… read more here.
Keywords: degradation; brexpiprazole bulk; method; brexpiprazole ... See more keywords
O7.5. LONG-TERM SAFETY AND TOLERABILITY OF BREXPIPRAZOLE IN PATIENTS WITH SCHIZOPHRENIA
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby015.234
Abstract: Abstract Background Long-term maintenance treatment is recommended to control the symptoms of schizophrenia1,2; therefore, safety monitoring for longer than the period required to treat an acute exacerbation is warranted. The aim of the present study… read more here.
Keywords: week; long term; treatment; safety ... See more keywords
Adjunctive Brexpiprazole as a Novel Effective Strategy for Treating Major Depressive Disorder: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000000622
Abstract: Purpose/Background Brexpiprazole was approved for adjunctive treatment of major depressive disorder (MDD) in 2015. Because only a small number of randomized controlled trials have investigated the use of brexpiprazole in MDD, we performed a meta-analysis.… read more here.
Keywords: depressive disorder; analysis; major depressive; brexpiprazole ... See more keywords
The Use of Brexpiprazole Combined With a Stimulant in Adults With Treatment-Resistant Attention-Deficit/Hyperactivity Disorder
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000001592
Abstract: Abstract Background This is the first controlled pharmacologic study in either adults or children with uncomplicated, treatment-resistant attention-deficit/hyperactivity disorder (ADHD). This study augmented stimulant therapy with the atypical antipsychotic brexpiprazole. The Food and Drug Administration… read more here.
Keywords: attention deficit; treatment; brexpiprazole; treatment resistant ... See more keywords
Silybin enhances the blood concentration of brexpiprazole in rats by downregulating expression of CYP3A4 and CYP2D6.
Sign Up to like & getrecommendations! Published in 2020 at "Die Pharmazie"
DOI: 10.1691/ph.2020.9935
Abstract: In this study, we investigated the effect of silybin on the pharmacokinetics of brexpiprazole and the underlying mechanism in rats. Two groups of animals received silybin at different doses (50 mg/kg, 25 mg/kg) for 2… read more here.
Keywords: concentration brexpiprazole; blood concentration; cyp3a4 cyp2d6; brexpiprazole ... See more keywords