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   Articles with "brg1" as a keyword



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Altered expression of BRG1 and histone demethylases, and aberrant H3K4 methylation in less developmentally competent embryos at the time of embryonic genome activation

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recommendations! Published in 2017 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.22762

Abstract: Epigenetics is a fundamental regulator underlying many biological functions, such as development and cell differentiation. Epigenetic modifications affect key chromatin regulation, including transcription and DNA repair, which are critical for normal embryo development. In this… read more here.

Keywords: embryonic genome; methylation; brg1; genome activation ... See more keywords

Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells

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recommendations! Published in 2018 at "STEM CELLS"

DOI: 10.1002/stem.2909

Abstract: Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor that is refractory to existing therapeutic regimens, which reflects the presence of stem‐like cells, termed glioma‐initiating cells (GICs). The complex interactions between different signaling… read more here.

Keywords: brg1; chromatin remodeling; stemness chemosensitivity; initiating cells ... See more keywords
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BRG1 is correlated with poor prognosis in colorectal cancer.

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recommendations! Published in 2018 at "Human pathology"

DOI: 10.1016/j.humpath.2017.12.013

Abstract: Brahma-related gene 1 (BRG1), a component of the chromatin-remodeling complex, regulates transcription by remodeling the chromatin structure. The present study aimed to elucidate the clinicopathological significance and prognostic role of BRG1 in colorectal cancer (CRC).… read more here.

Keywords: brg1 expression; brg1; poor prognosis; expression ... See more keywords

Phosphorylation of Ser1452 on BRG1 inhibits the function of the SWI/SNF complex in chromatin activation.

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recommendations! Published in 2021 at "Journal of proteomics"

DOI: 10.1016/j.jprot.2021.104319

Abstract: BRG1, one of core subunits of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancers. Previously, we reported significant downregulation of the phosphorylation level of BRG1 on Ser1452 ( read more here.

Keywords: brg1; chromatin; histone; swi snf ... See more keywords

The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation.

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recommendations! Published in 2020 at "Developmental biology"

DOI: 10.1016/j.ydbio.2020.05.008

Abstract: Chromatin-remodeling complexes play critical roles in establishing gene expression patterns in response to developmental signals. How these epigenetic regulators determine the fate of progenitor cells during development of specific organs is not well understood. We… read more here.

Keywords: brg1; proliferation; nephron progenitor; swi snf ... See more keywords
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Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling

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recommendations! Published in 2022 at "British Journal of Nutrition"

DOI: 10.1017/s0007114522001544

Abstract: Abstract Several amino acids can stimulate milk synthesis in mammary epithelial cells (MEC); however, the regulatory role of isoleucine (Ile) and underlying molecular mechanism remain poorly understood. In this study, we aimed to evaluate the… read more here.

Keywords: synthesis; expression; milk; brg1 ... See more keywords
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SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-06038-y

Abstract: Brg1/SMARCA4 serves as the ATPase and the helicase catalytic subunit for the multi-component SWI/SNF chromatin remodeling complex, which plays a pivotal role in governing chromatin structure and gene transcription. However, the upstream signaling pathways regulating… read more here.

Keywords: gastric cancer; cancer metastasis; brg1; fbw7 ... See more keywords

OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR

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recommendations! Published in 2022 at "Communications Biology"

DOI: 10.1038/s42003-022-03133-1

Abstract: Ovarian tumor (OTU) subfamily deubiquitinases are involved in various cellular processes, such as inflammation, ferroptosis and tumorigenesis; however, their pathological roles in prostate cancer (PCa) remain largely unexplored. In this study, we observed that several… read more here.

Keywords: prostate tumorigenesis; otud6a; brg1; pca ... See more keywords
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Brg1 subunit of chromatin remodelling complex is present during Chara vulgaris (Charophyceae) spermatogenesis

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recommendations! Published in 2018 at "European Journal of Phycology"

DOI: 10.1080/09670262.2018.1480803

Abstract: ABSTRACT During spermatogenesis, cells developed as a result of numerous mitotic and meiotic divisions transform into mature spermatozoids. In spermatids, remodelling of chromatin structure takes place which is connected with nuclear protein exchange, DNA double… read more here.

Keywords: brg1; chromatin remodelling; vulgaris; subunit ... See more keywords
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Loss of BAF (mSWI/SNF) chromatin-remodeling ATPase Brg1 causes multiple malformations of cortical development in mice.

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recommendations! Published in 2022 at "Human molecular genetics"

DOI: 10.1093/hmg/ddac127

Abstract: Mutations in genes encoding subunits of the BAF (BRG1/BRM-associated factor) complex cause various neurodevelopmental diseases. However, the underlying pathophysiology remains largely unknown. Here, we analyzed the function of Brg1, a core ATPase of BAF complexes,… read more here.

Keywords: brg1 causes; malformations cortical; cortical development; baf ... See more keywords
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The Role of BRG1 in Antioxidant and Redox Signaling

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recommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2020/6095673

Abstract: Redox homeostasis is regulated by critical molecules that modulate antioxidant and redox signaling (ARS) within the cell. Imbalances among these molecules can lead to oxidative stress and damage to cell functions, causing a variety of… read more here.

Keywords: brg1; antioxidant redox; role brg1; role ... See more keywords