Evaluation of binding and antagonism/downregulation of brilanestrant molecule in estrogen receptor-α via quantum mechanics/molecular mechanics, molecular dynamics and binding free energy calculations
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DOI: 10.1080/07391102.2019.1574605
Abstract: Abstract The resistance to the endocrine therapy of breast cancer leads to the emergence of new class of drugs that downregulates the estrogen receptor action known as selective estrogen receptor downregulators (SERDs). The first approved… read more here.
Keywords: molecule; bri molecule; mechanics molecular; estrogen receptor ... See more keywords