Structural Insights into the Role of Pseudouridimycin Binding in Disruption of Bacterial RNA Polymerase Bridge Helix Conformational Arrangement.
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DOI: 10.2174/1389201023666220511211433
Abstract: BACKGROUND The bridge helix (BH) is a crucial region involved in bacterial RNA polymerase (RNAP) catalysis. It plays an essential role in the nucleotide addition cycle (NAC) by performing many modulated rearrangements and conformational changes.… read more here.
Keywords: role; bacterial rna; bridge helix; pum ... See more keywords