Bridged bicyclic peptides: Structure and function
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DOI: 10.1002/pep2.24057
Abstract: Bicyclic peptides are conformationally rigid molecules that can bind with high affinity and specificity to their protein target, yet are significantly more protease stable than their linear or monocyclic counterparts. This emerging class of peptides… read more here.
Keywords: bridged bicyclic; peptides structure; structure function; bicyclic peptides ... See more keywords
Ribosomal Synthesis of Thioether-Bridged Bicyclic Peptides.
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DOI: 10.1007/978-1-4939-6451-2_5
Abstract: Many biologically active peptides found in nature exhibit a bicyclic structure wherein a head-to-tail cyclic backbone is further constrained by an intramolecular linkage connecting two side chains of the peptide. Accordingly, methods to access macrocyclic… read more here.
Keywords: bridged bicyclic; ribosomal synthesis; thioether bridged; synthesis thioether ... See more keywords
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II).
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103020
Abstract: Despite recent advancements in its control, malaria is still a deadly parasitic disease killing millions of people each year. Progresses in combating the infection have been made by using the so-called artemisinin combination therapies (ACTs).… read more here.
Keywords: biomimetic reaction; bridged bicyclic; reaction; structure activity ... See more keywords