Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies.
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DOI: 10.1016/j.bioorg.2018.02.027
Abstract: A number of pyrimidine bridged combretastatin derivatives were designed, synthesized and evaluated for anticancer activities against breast cancer (MCF-7) and lung cancer (A549) cell lines using MTT assays. Most of the synthesized compounds displayed good… read more here.
Keywords: biological evaluation; bridged combretastatin; combretastatin derivatives; cancer ... See more keywords