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Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800702
Abstract: Oligonucleotides containing bridged nucleic acids (BNAs) show high duplex‐forming ability towards target single‐stranded RNA, so many BNAs have been developed for antisense applications. Amide‐bridged nucleic acids (AmNAs), which are BNA analogues bearing an amide bond…
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Keywords:
duplex forming;
forming ability;
thioamna;
bridged nucleic ... See more keywords
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Published in 2021 at "Current Organic Chemistry"
DOI: 10.2174/1385272825666210625122342
Abstract: Bridged nucleic acids (BNA) or locked nucleic acids (LNA) are a class of nucleic acids modification, which is obtained by connecting the 2'-O and 4'-C of ribose sugar using a methylene bridge. This ‘bridging or…
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Keywords:
nucleic acids;
bridged nucleic;
advances synthesis;
bna ... See more keywords
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Published in 2021 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.17.54
Abstract: Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an N-methylguanidine-bridged nucleic acid…
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Keywords:
bridged nucleic;
methylguanidine bridged;
guna;
oligonucleotides modified ... See more keywords