Disulfide-Bridged Peptides That Mediate Enantioselective Cycloadditions through Thiyl Radical Catalysis.
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DOI: 10.1021/acs.orglett.8b00364
Abstract: An enantioselective vinylcyclopropane ring-opening/cycloaddition cascade is described. The active thiyl radical catalysts are generated in situ via UV light-promoted homolysis of cystine-based dimers. Amide-functionalization of the peptide at the 4-proline position is essential for effective… read more here.
Keywords: mediate enantioselective; thiyl radical; enantioselective cycloadditions; disulfide bridged ... See more keywords