Organocatalytic Asymmetric Synthesis of Bridged Tetrahydrobenzo[b]azepines/oxepines.
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DOI: 10.1021/acs.orglett.2c02833
Abstract: The asymmetric synthesis of bridged tetrahydrobenzo[b]azepine and oxepine derivatives through chiral Brønsted acid catalyzed asymmetric aza-Piancatelli rearrangement/Michael addition sequence has been developed. The reaction proceeds under mild reaction conditions to afford the final bridged cyclic… read more here.
Keywords: bridged tetrahydrobenzo; organocatalytic asymmetric; tetrahydrobenzo azepines; synthesis bridged ... See more keywords