Apelin-13 analogues show potent in vitro and in vivo insulinotropic and glucose lowering actions
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DOI: 10.1016/j.peptides.2017.12.004
Abstract: HighlightsN‐ and C‐terminally structurally modified peptide analogues of apelin‐13 are more stable than the native peptide and retain bioactivity.Apelin‐13 analogues produce a strong dose‐dependent insulinotropic response in cultured pancreatic BRIN‐BD11 cells and isolated mouse islets.Apelin‐13… read more here.
Keywords: apelin; bd11 cells; apelin analogues; brin bd11 ... See more keywords