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Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1264
Abstract: The pharmacokinetics, metabolism, safety, and tolerability of the antiseizure medication brivaracetam (BRV) were characterized in 16 healthy elderly participants (8 men/8 women) aged 65-78 years who received a single 200-mg oral dose of BRV on day…
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Keywords:
brivaracetam;
healthy elderly;
safety tolerability;
elderly participants ... See more keywords
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Published in 2020 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2020.106327
Abstract: Brivaracetam is an antiepileptic drug (AED) indicated for the treatment of focal seizures, with improved safety and tolerability vs first-generation AEDs. Brivaracetam binds with high affinity to synaptic vesicle protein 2A in the brain, which…
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Keywords:
brivaracetam;
drug interactions;
drug;
review drug ... See more keywords
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Published in 2017 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2017.1366985
Abstract: ABSTRACT Introduction: Brivaracetam (BRV) is a new AED currently licensed for the adjunctive treatment of adult patients with focal epilepsies. It is a ligand of the ubiquitous synaptic vesicle glycoprotein 2A (SV2A). Areas covered: This…
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Keywords:
brivaracetam;
preclinical discovery;
treatment;
brv ... See more keywords
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Published in 2022 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsac077
Abstract: BACKGROUND Recently, quantitative nuclear magnetic resonance (qNMR) competes with separation techniques like HPLC and capillary electrophoresis for quantification purposes when dealing with molecules that lack a chromophore. OBJECTIVE The advantages of the proton nuclear magnetic…
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Keywords:
approach optimization;
practice;
brivaracetam;
taguchi approach ... See more keywords
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Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17187
Abstract: To evaluate the pharmacokinetics, safety, and tolerability of brivaracetam (BRV) as 15‐min intravenous (IV) infusion and bolus (≤2‐min injection).
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Keywords:
tolerability intravenous;
brivaracetam;
safety tolerability;
pharmacokinetics safety ... See more keywords
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Published in 2019 at "Molecular Pain"
DOI: 10.1177/1744806919886503
Abstract: Background The antiseizure racetams may provide novel molecular insights into neuropathic pain due to their unique mechanism involving synaptic vesicle glycoprotein 2A. Anti-allodynic effects of levetiracetam have been shown in animal models of neuropathic pain.…
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Keywords:
brivaracetam;
vesicle glycoprotein;
neuropathic pain;
synaptic vesicle ... See more keywords
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Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s103468
Abstract: Currently, a number of novel anticonvulsant drugs, the so-called third generation, are in various stages of development. Several of them are already available or in ongoing clinical trials. These new compounds should take advantage of…
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Keywords:
brivaracetam;
partial onset;
drug;
anticonvulsant drugs ... See more keywords