Pharmacokinetics, Safety, and Tolerability of Brivaracetam in Healthy Elderly Participants.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1264
Abstract: The pharmacokinetics, metabolism, safety, and tolerability of the antiseizure medication brivaracetam (BRV) were characterized in 16 healthy elderly participants (8 men/8 women) aged 65-78 years who received a single 200-mg oral dose of BRV on day… read more here.
Keywords: brivaracetam; healthy elderly; safety tolerability; elderly participants ... See more keywords
Efficacy and safety of Brivaracetam as adjunctive therapy in pediatric epilepsy: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2025 at "Neurological Sciences"
DOI: 10.1007/s10072-025-08185-9
Abstract: Brivaracetam is a novel third-generation antiseizure medication and an analog of levetiracetam with selective affinity for synaptic vesicle protein 2A (SV2A). By binding SV2A, brivaracetam decreases pre-synaptic neurotransmitter release. We aimed to assess the safety… read more here.
Keywords: pediatric epilepsy; analysis; safety brivaracetam; epilepsy ... See more keywords
A review of the drug−drug interactions of the antiepileptic drug brivaracetam
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2020.106327
Abstract: Brivaracetam is an antiepileptic drug (AED) indicated for the treatment of focal seizures, with improved safety and tolerability vs first-generation AEDs. Brivaracetam binds with high affinity to synaptic vesicle protein 2A in the brain, which… read more here.
Keywords: brivaracetam; drug interactions; drug; review drug ... See more keywords
Neuroprotective Effect of Brivaracetam and Perampanel Combination on Electrographic Seizures and Behavior Anomalies in Pentylenetetrazole-Kindled Mice
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c00962
Abstract: Pentylenetetrazole (PTZ)-induced kindling is a broadly used experimental model to study the anticonvulsive potential of new and existing chemical moieties with the aim of discovering drugs hindering seizure progression and associated neurological comorbidities. In the… read more here.
Keywords: combination; kindled mice; brivaracetam; ptz ... See more keywords
The preclinical discovery and development of brivaracetam for the treatment of focal epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2017.1366985
Abstract: ABSTRACT Introduction: Brivaracetam (BRV) is a new AED currently licensed for the adjunctive treatment of adult patients with focal epilepsies. It is a ligand of the ubiquitous synaptic vesicle glycoprotein 2A (SV2A). Areas covered: This… read more here.
Keywords: brivaracetam; preclinical discovery; treatment; brv ... See more keywords
Taguchi Approach for Optimization of a Green Quantitative 1H-NMR Practice for Characterization of Levetiracetam and Brivaracetam in Pharmaceuticals.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsac077
Abstract: BACKGROUND Recently, quantitative nuclear magnetic resonance (qNMR) competes with separation techniques like HPLC and capillary electrophoresis for quantification purposes when dealing with molecules that lack a chromophore. OBJECTIVE The advantages of the proton nuclear magnetic… read more here.
Keywords: approach optimization; practice; brivaracetam; taguchi approach ... See more keywords
Pharmacokinetics, safety, and tolerability of intravenous brivaracetam in pediatric patients with epilepsy: An open‐label trial
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17187
Abstract: To evaluate the pharmacokinetics, safety, and tolerability of brivaracetam (BRV) as 15‐min intravenous (IV) infusion and bolus (≤2‐min injection). read more here.
Keywords: tolerability intravenous; brivaracetam; safety tolerability; pharmacokinetics safety ... See more keywords
Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Pain"
DOI: 10.1177/1744806919886503
Abstract: Background The antiseizure racetams may provide novel molecular insights into neuropathic pain due to their unique mechanism involving synaptic vesicle glycoprotein 2A. Anti-allodynic effects of levetiracetam have been shown in animal models of neuropathic pain.… read more here.
Keywords: brivaracetam; vesicle glycoprotein; neuropathic pain; synaptic vesicle ... See more keywords
New developments in the management of partial-onset epilepsy: role of brivaracetam
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s103468
Abstract: Currently, a number of novel anticonvulsant drugs, the so-called third generation, are in various stages of development. Several of them are already available or in ongoing clinical trials. These new compounds should take advantage of… read more here.
Keywords: brivaracetam; partial onset; drug; anticonvulsant drugs ... See more keywords
Respuesta clínica a brivaracetam en dos casos de epilepsia de ausencia juvenil farmacorresistentes
Sign Up to like & getrecommendations! Published in 2025 at "Anales del Sistema Sanitario de Navarra"
DOI: 10.23938/assn.1132
Abstract: RESUMEN Si bien solo el 20% de las personas con epilepsias generalizadas idiopáticas son farmacorresistentes, dicho porcentaje resulta bastante problemático si se toma en cuenta los escasos fármacos aprobados para este tipo de epilepsia. Solo… read more here.
Keywords: epilepsia ausencia; casos; ausencia juvenil; brivaracetam ... See more keywords