A broad and potent neutralization epitope in SARS-related coronaviruses
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205784119
Abstract: Significance Since the beginning of the COVID-19 pandemic, many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have emerged that are resistant to varying extents to neutralizing antibody responses induced by current vaccines and natural… read more here.
Keywords: broad potent; potent neutralization; sars related; epitope ... See more keywords
Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220948120
Abstract: The antiviral benefit of antibodies can be compromised by viral escape especially for rapidly evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to counter newly emerging, diverse strains. Discovery of such… read more here.
Keywords: broad potent; constrained regions; functionally constrained; breakthrough infection ... See more keywords
Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1049867
Abstract: More than 80% of SARS-CoV-2 variants, including Alpha and Omicron, contain an N501Y mutation in the receptor-binding domain (RBD) of the spike protein. The N501Y change is an adaptive mutation enabling tighter interaction with the… read more here.
Keywords: broad potent; centric antibody; n501y centric; cross reactivity ... See more keywords
A Broad and Potent H1-Specific Human Monoclonal Antibody Produced in Plants Prevents Influenza Virus Infection and Transmission in Guinea Pigs
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DOI: 10.3390/v12020167
Abstract: Although seasonal influenza vaccines block most predominant influenza types and subtypes, humans still remain vulnerable to waves of seasonal and new potential pandemic influenza viruses for which no immunity may exist because of viral antigenic… read more here.
Keywords: kpf1 antx; human monoclonal; hmab; broad potent ... See more keywords