Broad-Scope (3 + 2) Cycloaddition of Cyclopropanes and Alkynes Enabled by Boronyl Radical Catalysis.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c02565
Abstract: Cyclopentene skeletons are ubiquitous in natural products and small molecule drugs. The (3 + 2) cycloaddition of cyclopropanes and alkynes represents an efficient and atom-economic strategy for synthesizing these structures. However, the types of substituents… read more here.
Keywords: broad scope; cycloaddition cyclopropanes; cyclopropanes alkynes; scope cycloaddition ... See more keywords
4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase.
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.4c00011
Abstract: Acetylcholinesterase (AChE) inhibition by organophosphorus (OP) compounds poses a serious health risk to humans. While many therapeutics have been tested for treatment after OP exposure, there is still a need for efficient reactivation against all… read more here.
Keywords: quinone methide; methide precursors; reactivation; broad scope ... See more keywords