A broadly applicable, stress-mediated bacterial death pathway regulated by the phosphotransferase system (PTS) and the cAMP-Crp cascade
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118566119
Abstract: Significance Finding that pan-tolerance derives from defects in carbohydrate regulation connects stress-mediated lesions with metabolic change, identifies a stable type of tolerance, and demonstrates a widely shared death response. Manipulation of the response should improve… read more here.
Keywords: stress mediated; pan tolerance; death; tolerance ... See more keywords
Identification of Broadly Applicable Adeno-Associated Virus Vectors by Systematic Comparison of Commonly Used Capsid Variants In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Human Gene Therapy"
DOI: 10.1089/hum.2022.109
Abstract: Adeno-associated viruses (AAVs) represent highly attractive gene therapy vectors and potent research tools for the modulation of gene expression in animal models or difficult-to-transfect cell cultures. Engineered variants, comprising chimeric, mutated, or peptide-inserted capsids, have… read more here.
Keywords: cell; adeno associated; identification broadly; broadly applicable ... See more keywords
Novel and Broadly Applicable Microsatellite Markers in Identified Chromosomes of the Philippine Dengue Mosquitoes, Aedes aegypti (Diptera: Culicidae)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Entomology"
DOI: 10.1093/jme/tjab194
Abstract: Abstract Dengue is the leading arboviral infection in the Philippines. Its endemicity in the country is due to the presence of its primary mosquito vector, Aedes aegypti (L.). This species has limited microsatellite markers. This… read more here.
Keywords: aedes aegypti; mendelian codominant; dengue; chromosome ... See more keywords
Broadly Applicable Control Approaches Improve Accuracy of ChIP-Seq Data
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119271
Abstract: Chromatin ImmunoPrecipitation (ChIP) is a widely used method for the analysis of protein–DNA interactions in vivo; however, ChIP has pitfalls, particularly false-positive signal enrichment that permeates the data. We have developed a new approach to… read more here.
Keywords: control; chip seq; non specific; broadly applicable ... See more keywords