Structure‐based discovery of small molecules improving stability of human broadly‐neutralizing anti‐HIV antibody 2F5 in plant suspension cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202100266
Abstract: The production of biopharmaceuticals in engineered plant‐based systems is a promising technology that has proven its suitability for the production of various recombinant glyco–proteins that are currently undergoing clinical trials. However, compared to mammalian cell… read more here.
Keywords: broadly neutralizing; human broadly; neutralizing anti; anti hiv ... See more keywords
Analytical characterization of broadly neutralizing antibody CAP256LS heavy chain clipping during manufacturing development
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DOI: 10.1002/btpr.3296
Abstract: Broadly neutralizing antibody (bNAb) CAP256‐VRC26.25 (abbreviated CAP256LS), a human IgGI monoclonal antibody targeting the V1V2 site of the HIV‐1 envelope, has demonstrated high therapeutic potential as a broadly neutralizing monoclonal antibody against HIV‐1. During the… read more here.
Keywords: heavy chain; analytical characterization; broadly neutralizing; development ... See more keywords
Broadly neutralizing antibodies recognizing different antigenic epitopes act synergistically against the influenza B virus
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DOI: 10.1002/jmv.28106
Abstract: The discovery of broadly neutralizing monoclonal antibodies against influenza viruses has raised hope for the successful development of new antiviral drugs. However, due to the speed and variety of mutations in influenza viruses, single‐component antibodies… read more here.
Keywords: antibodies recognizing; different antigenic; broadly neutralizing; recognizing different ... See more keywords
Broadly Neutralizing Antibodies to Highly Antigenically Variable Viruses as Templates for Vaccine Design.
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DOI: 10.1007/82_2020_221
Abstract: Development of vaccines to highly variable viruses such as Human Immunodeficiency Virus and influenza A viruses faces multiple challenges. In this article, these challenges are described and reverse vaccinology approaches to generate universal vaccines against… read more here.
Keywords: antigenically variable; variable viruses; antibodies highly; highly antigenically ... See more keywords
Evaluation of susceptibility of HIV-1 CRF01_AE variants to neutralization by a panel of broadly neutralizing antibodies
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DOI: 10.1007/s00705-018-4011-7
Abstract: Broadly neutralizing antibodies (bNAbs) are very promising agents for HIV-1 prophylaxis and AIDS treatment. However, the neutralization susceptibility of circulating recombinants such as CRF01_AE, which is becoming increasingly prevalent, has not been studied in detail… read more here.
Keywords: susceptibility; neutralizing antibodies; pg9 pg16; evaluation susceptibility ... See more keywords
Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity
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DOI: 10.1016/j.celrep.2018.04.101
Abstract: Summary Human high-affinity antibodies to pathogens often recognize unrelated ligands. The molecular origin and the role of this polyreactivity are largely unknown. Here, we report that HIV-1 broadly neutralizing antibodies (bNAbs) are frequently polyreactive, cross-reacting… read more here.
Keywords: conformational plasticity; non hiv; hiv; polyreactivity ... See more keywords
VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2019.02.004
Abstract: Broadly neutralizing antibodies (bnAbs) are potential therapeutic molecules and valuable tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody responses to conserved epitopes can be highly convergent at the molecular level.… read more here.
Keywords: genetics; neutralizing antibodies; vh1 antiviral; antiviral broadly ... See more keywords
A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure
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DOI: 10.1016/j.immuni.2017.03.017
Abstract: &NA; Broadly neutralizing antibodies (bnAbs) to HIV delineate vaccine targets and are prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary epitope at the apex of the surface HIV envelope (Env)… read more here.
Keywords: apex; antibody; structure; broadly neutralizing ... See more keywords
HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage
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DOI: 10.1016/j.immuni.2017.11.002
Abstract: SUMMARY Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope (Env) develop during natural infection can help guide the rational design of an HIV vaccine. Here, we described a bnAb lineage targeting the Env V2… read more here.
Keywords: lineage; heterogeneity; env; glycoform heterogeneity ... See more keywords
Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
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DOI: 10.1016/j.immuni.2019.10.008
Abstract: Summary The elicitation of broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) trimer remains a major vaccine challenge. Most cross-conserved protein determinants are occluded by self-N-glycan shielding, limiting B cell recognition of the… read more here.
Keywords: envelope; trimer; neutralizing antibodies; vaccination glycan ... See more keywords
Functional Contacts between MPER and the Anti-HIV-1 Broadly Neutralizing Antibody 4E10 Extend into the Core of the Membrane.
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DOI: 10.1016/j.jmb.2017.03.008
Abstract: The exceptional breadth of broadly neutralizing antibodies (bNAbs) against the membrane-proximal external region (MPER) of the transmembrane protein gp41 makes this class of antibodies an ideal model to design HIV vaccines. From a practical point… read more here.
Keywords: antibody; apex region; anti hiv; membrane ... See more keywords