A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14234
Abstract: Influenza B virus (IBV) causes annual influenza epidemics around the world. Here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46B8 that neutralizes all IBVs tested in vitro and… read more here.
Keywords: broadly protective; antibody; protective therapeutic; therapeutic antibody ... See more keywords
Corrigendum: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15779
Abstract: This corrects the article DOI: 10.1038/ncomms14234. read more here.
Keywords: antibody influenza; influenza virus; protective therapeutic; therapeutic antibody ... See more keywords
Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes
Sign Up to like & getrecommendations! Published in 2017 at "Nature microbiology"
DOI: 10.1038/s41564-017-0011-8
Abstract: A substantial proportion of influenza-related childhood deaths are due to infection with influenza B viruses, which co-circulate in the human population as two antigenically distinct lineages defined by the immunodominant receptor binding protein, haemagglutinin. While… read more here.
Keywords: neuraminidase; murine; monoclonal antibodies; neuraminidase epitopes ... See more keywords
Hide and seek: interplay between influenza viruses and B cells.
Sign Up to like & getrecommendations! Published in 2020 at "International immunology"
DOI: 10.1093/intimm/dxaa028
Abstract: Influenza virus constantly acquires genetic mutations/reassortment in the major surface protein, hemagglutinin (HA), resulting in the generation of strains with antigenic variations. There are, however, HA epitopes that are conserved across influenza viruses and are… read more here.
Keywords: conserved epitopes; influenza viruses; influenza; hide seek ... See more keywords
Epitope-targeting platform for broadly protective influenza vaccines
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DOI: 10.1371/journal.pone.0252170
Abstract: Seasonal influenza vaccines are often ineffective because they elicit strain-specific antibody responses to mutation-prone sites on the hemagglutinin (HA) head. Vaccines that provide long-lasting immunity to conserved epitopes are needed. Recently, we reported a nanoparticle-based… read more here.
Keywords: epitope targeting; influenza vaccines; influenza; platform ... See more keywords
Broadly Protective Neuraminidase-Based Influenza Vaccines and Monoclonal Antibodies: Target Epitopes and Mechanisms of Action
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15010200
Abstract: Neuraminidase (NA) is an important surface protein on influenza virions, playing an essential role in the viral life cycle and being a key target of the immune system. Despite the importance of NA-based immunity, current… read more here.
Keywords: target epitopes; protective neuraminidase; influenza vaccines; broadly protective ... See more keywords