Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.11.056
Abstract: Summary The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell… read more here.
Keywords: anti idiotypic; antibody; reactive anti; broadly reactive ... See more keywords
Induction of broadly reactive influenza antibodies increases susceptibility to autoimmunity.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110482
Abstract: Infection and vaccination repeatedly expose individuals to antigens that are conserved between influenza virus subtypes. Nevertheless, antibodies recognizing variable influenza epitopes greatly outnumber antibodies reactive against conserved epitopes. Elucidating factors contributing to the paucity of… read more here.
Keywords: broadly reactive; susceptibility; reactive influenza; antibodies increases ... See more keywords
Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra01382k
Abstract: We have developed broadly reactive aptamers against multiple variants by alternating the target between spike proteins from different SARS-CoV-2 variants during the selection process. In this process we have developed aptamers which can recognise all… read more here.
Keywords: cov variants; broadly reactive; reactive aptamers; high affinity ... See more keywords
Development of broadly reactive influenza vaccines by targeting the conserved regions of the hemagglutinin stem and head domains
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2020.1777861
Abstract: ABSTRACT Introduction Influenza virus infections cause serious illness in millions of people each year. Although influenza virus vaccines are available, they are not optimally effective due to mismatches between the influenza virus strains used for… read more here.
Keywords: protection; influenza; broadly reactive; influenza virus ... See more keywords
A TCR Mimic CAR T Cell Specific for NDC80 Is Broadly Reactive With Solid Tumors and Hematological Malignancies.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021012882
Abstract: Target identification for CAR T cell therapies remains challenging due to the limited repertoire of tumor-specific surface proteins. Intracellular proteins presented in the context of cell surface HLA provide a wide pool of potential antigens… read more here.
Keywords: broadly reactive; mimic car; tcr mimic; cell ... See more keywords
The Ability of Porcine Reproductive and Respiratory Syndrome Virus Isolates to Induce Broadly Reactive Neutralizing Antibodies Correlates With In Vivo Protection
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.691145
Abstract: Porcine reproductive and respiratory syndrome (PRRS) is considered one of the most relevant diseases of swine. The condition is caused by PRRS virus (PRRSV), an extremely variable virus of the Arteriviridae family. Its heterogeneity can… read more here.
Keywords: protection; reactive nas; induce broadly; prrsv isolates ... See more keywords
Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1103765
Abstract: Currently licensed vaccine adjuvants offer limited mucosal immunity, which is needed to better combat respiratory infections such as influenza. Mast cells (MCs) are emerging as a target for a new class of mucosal vaccine adjuvants.… read more here.
Keywords: broadly reactive; influenza; self; vaccine ... See more keywords
Vaccination with Consensus H7 Elicits Broadly Reactive and Protective Antibodies against Eurasian and North American Lineage H7 Viruses
Sign Up to like & getrecommendations! Published in 2020 at "Vaccines"
DOI: 10.3390/vaccines8010143
Abstract: H7 subtype avian influenza viruses have caused outbreaks in poultry, and even human infection, for decades in both Eurasia and North America. Although effective vaccines offer the best protection against avian influenza viruses, antigenically distinct… read more here.
Keywords: eurasian north; consensus; broadly reactive; american lineage ... See more keywords