The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13033-8
Abstract: Chlorination of drinking water protects humans from water-born pathogens, but it also produces low concentrations of dibromoacetonitrile (DBAN), a common disinfectant by-product found in many water supply systems. DBAN is not mutagenic but causes DNA… read more here.
Keywords: water; broken replication; delays transition; replication forks ... See more keywords
A Rfa1-MN–based system reveals new factors involved in the rescue of broken replication forks
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011405
Abstract: The integrity of the replication forks is essential for an accurate and timely completion of genome duplication. However, little is known about how cells deal with broken replication forks. We have generated in yeast a… read more here.
Keywords: replication; system; rfa1 based; broken replication ... See more keywords