Metabolite Profiling and Reaction Phenotyping for the in vitro Assessment of the Bioactivation of Bromfenac.
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DOI: 10.1021/acs.chemrestox.9b00268
Abstract: Bromfenac is a non-steroidal anti-inflammatory drug that was approved and subsequently withdrawn from the market due to reported cases of acute hepatotoxicity. Recently, in vitro studies have revealed that bromfenac requires UDPGA and alamethicin supplemented… read more here.
Keywords: profiling reaction; bioactivation; metabolite profiling; bromfenac ... See more keywords
EFFECT OF BROMFENAC ON PAIN RELATED TO INTRAVITREAL INJECTIONS: A Randomized Crossover Study
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DOI: 10.1097/iae.0000000000001137
Abstract: Purpose: To evaluate the analgesic effect of bromfenac, a topically administered nonsteroidal antiinflammatory agent, in patients undergoing intravitreal injections (IVIs) of anti–vascular endothelial growth factor agents. Methods: A single center, prospective, randomized, double-blind, placebo-controlled, cross… read more here.
Keywords: effect bromfenac; study; short form; intravitreal injections ... See more keywords
VITREOUS PROSTAGLANDIN E2 CHANGES AFTER TOPICAL ADMINISTRATION OF DICLOFENAC 0.1%, INDOMETHACIN 0.5%, NEPAFENAC 0.3%, AND BROMFENAC 0.09.
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DOI: 10.1097/iae.0000000000002674
Abstract: PURPOSE To evaluate the vitreous concentration of different nonsteroidal anti-inflammatory drugs (NSAIDs) after topical administration and the related prostaglandin E2 (PGE2) levels in patients undergoing pars plana vitrectomy. METHODS A prospective, randomized, investigator-masked study was… read more here.
Keywords: diclofenac indomethacin; bromfenac; indomethacin nepafenac; pge2 levels ... See more keywords
Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys
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DOI: 10.1111/cts.13047
Abstract: The impact of organic anion‐transporting polypeptide (OATP) inhibition on systemic and liver exposures of three OATP substrates was investigated in cynomolgus monkeys. A monkey physiologically‐based pharmacokinetic (PBPK) model was constructed to describe the exposure changes… read more here.
Keywords: inhibition; exposure; liver; model ... See more keywords
Comparative study of the efficacy and safety of bromfenac, nepafenac and diclofenac sodium for the prevention of cystoid macular edema after phacoemulsification.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2018.07.22
Abstract: AIM To compare the efficacy, tolerability and safety of bromfenac 0.09%, nepafenac 0.1% or diclofenac 0.1% for the prophylaxis of the cystoid macular edema (CME) after phacoemulsification. METHODS Group sequential observational comparative study. After phacoemulsification,… read more here.
Keywords: bromfenac; bromfenac nepafenac; diclofenac sodium; phacoemulsification ... See more keywords