Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent
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DOI: 10.1039/d3ra00088e
Abstract: A simple and effective method for the copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides with ethyl bromodifluoroacetate as the bifunctional reagent was developed. The combination of cupric catalyst and alkaline additive results in… read more here.
Keywords: difluoromethylation; bromination difluoromethylation; bromination; copper catalyzed ... See more keywords