An unusual rearrangement involving 5-bromo-1-phenylpyridone during its methyl cross coupling with turbo-Grignard reagent, leading to a 5-bromopyridone-fused seven-membered carbocyclic ring
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-017-2159-9
Abstract: The structure of a cyclohepta[c]pyridin-1-one, a product of an unusual transformation, isolated during a turbo-Grignard reagentpromoted methyl cross coupling to 5-bromo-1-phenyl-2-pyridone, was determined by 1H and 13C NMR, COSY and high-resolution MS, as well as… read more here.
Keywords: methyl cross; turbo grignard; cross coupling; bromo ... See more keywords
Investigation on terpolymer of ethylene/propylene/ω-bromo-α-olefins catalyzed by titanium complexes
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DOI: 10.1007/s10853-017-0834-y
Abstract: Polyolefins with polar groups exhibited many applications as high-performance materials have been the subject of considerable research. In this study, terpolymers of ω-bromo-α-olefins with ethylene and propylene were synthesized in the presence of three multi-chelated… read more here.
Keywords: bromo; ethylene propylene; bromo olefins; titanium complexes ... See more keywords
Comparative toxicity of chloro- and bromo-nitromethanes in mice based on a metabolomic method.
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DOI: 10.1016/j.chemosphere.2017.06.116
Abstract: Halonitromethanes (HNMs) as one typical class of nitrogenous disinfection byproducts have been widely found in drinking water. In vitro test found HNMs could induce higher cytotoxicity and genotoxicity than trihalomethanes and haloacetic acids. However, data on… read more here.
Keywords: toxicity chloro; bromo; toxicity; three hnms ... See more keywords
Facile synthesis of bromo- and mixed bromo/chloro dibenzo-p-dioxins and [14C]-labeled 1,3,7,8-tetrabromodibenzo-p-dioxin.
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DOI: 10.1016/j.chemosphere.2019.124626
Abstract: Polybrominated dibenzo-p-dioxins (PBDDs) and mixed bromo/chloro dibenzo-p-dioxins (PXDDs) are persistent organic pollutants that can possess the same toxicity as their fully chlorinated analogs (PCDDs) and have been identified in the same matrices. Herein a general… read more here.
Keywords: dibenzo dioxins; mixed bromo; bromo; bromo chloro ... See more keywords
Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113976
Abstract: Our previous studies on FabG have identified two compounds 5-bromo-2-(thiophene-2-carboxamido) benzoic acid (A) and ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate(B) as best hits with allosteric mode of inhibition. FabG is an integral part of bacterial fatty acid biosynthetic system… read more here.
Keywords: bromo; benzoic acid; acid; bromo thiophene ... See more keywords
GC–MS and GC–IR analysis of substituted N-benzyl 4-bromo-2,5-dimethoxyphenylisopropylamines
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DOI: 10.1016/j.forc.2021.100326
Abstract: Abstract The N-(methoxybenzyl- and dimethoxybenzyl)-4-bromo-2,5-dimethoxyphenylisopropylamines are a likely category of novel psychoactive substances based on a combination of structural features for the amphetamine and the NBOMe drugs. The nine compounds in this study were synthesized… read more here.
Keywords: analysis substituted; aromatic ring; benzyl bromo; substituted benzyl ... See more keywords
Efficient ortho-formylation in vitamin E series, application to the semi-synthesis of natural 5- and 7-formyl-δ-tocotrienols revealing an unprecedented 5-bromo-7-formyl exchange
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DOI: 10.1016/j.tet.2017.10.039
Abstract: Semi-synthesis of 5- and 7-formyltocopherols and tocotrienols has been developed by ortho-formylation of C-5 or C-7-unsubstituted vitamin E derivatives (14 examples) up to 90% yield, through heating in the presence of respectively 10-10-15 equivalents of… read more here.
Keywords: bromo; bromo formyl; ortho formylation; semi synthesis ... See more keywords
Facile synthesis of bromo- and iodo-1,2,3-triazoles
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DOI: 10.1016/j.tetlet.2017.07.016
Abstract: Abstract Facile synthetic routes to bromo- and iodo-1,2,3-triazoles were achieved. Diiodo-1,2,3-triazole was directly obtained from 1,2,3-triazole, and dihalo-1,2,3-triazoles were converted to halo-1,2,3-triazoles in good yields without protection by NH. Unsymmetrical 4-bromo-5-iodo-1,2,3-triazole was synthesized from bromo-1,2,3-triazole.… read more here.
Keywords: facile synthesis; iodo triazoles; bromo; bromo iodo ... See more keywords
Practical synthesis of 16α-bromo-17α-hydroxysteroids via a Raney Ni-catalyzed bromide exchange reaction
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DOI: 10.1016/j.tetlet.2019.05.049
Abstract: Abstract D-ring modified glucocorticoids are attractive synthetic targets owing to their broad application in medicinal chemistry. Herein, we reported a practical synthesis of 16α-bromo-17α-hydroxysteroids from easily available 16β-bromo isomers via a Raney Ni-catalyzed bromide exchange… read more here.
Keywords: via raney; reaction; bromo hydroxysteroids; synthesis bromo ... See more keywords
Regio- and Stereoselective N-addition to an Open Bromo Vinyl Cation
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DOI: 10.1016/j.tetlet.2021.153173
Abstract: Abstract A protocol for the synthesis of thus far inaccessible bromo vinyl triflimides is presented. Our previously reported concept of assisted vinyl cation formation was engaged to achieve both a protonation of relatively electron poor… read more here.
Keywords: cation; vinyl cation; stereoselective addition; bromo vinyl ... See more keywords
Bromo-dragonfly, a psychoactive benzodifuran, is resistant to hepatic metabolism and potently inhibits monoamine oxidase A.
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DOI: 10.1016/j.toxlet.2018.07.018
Abstract: Bromo-dragonfly is a benzodifuran derivative known as one of the most potent 5-HT2A-receptor agonists within this chemical class, with long-lasting effects of up to 2-3 days. In addition to hallucinogenic effects, the drug is a… read more here.
Keywords: bromo; bromo dragonfly; hepatic metabolism; monoamine oxidase ... See more keywords