Synthesis of Secondary Trifluoromethylated Alkyl Bromides Using 2-Bromo-3,3,3-trifluoropropene as a Radical Acceptor.
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DOI: 10.1021/acs.orglett.2c00425
Abstract: Herein, the first example using commercially available 2-bromo-3,3,3-trifluoropropene (BTP) as a radical acceptor has been reported. Taking advantage of this strategy, a wide range of secondary trifluoromethylated alkyl bromides were synthesized in good to excellent… read more here.
Keywords: bromo trifluoropropene; alkyl bromides; secondary trifluoromethylated; trifluoromethylated alkyl ... See more keywords
Relay Photocatalytic Reaction of N-Aryl Amino Acids and 2-Bromo-3,3,3-trifluoropropene: Synthesis of 4-(Difluoromethylidene)-tetrahydroquinolines.
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DOI: 10.1021/acs.orglett.2c01117
Abstract: The bulk industrial chemical 2-bromo-3,3,3-trifluoropropene (BTP) was first employed as a coupling partner in photocatalytic defluorinative reactions with N-aryl amino acids. Photoredox activation of the C(sp2)-Br bond of the resultant 2-bromo-1,1-difluoroalkenes generates gem-difluoro vinyl radicals… read more here.
Keywords: amino acids; difluoromethylidene tetrahydroquinolines; bromo trifluoropropene; aryl amino ... See more keywords