Highly Chemo-, Regio- and E/Z-Selective Intermolecular Heck-Type Dearomative [2 + 2 + 1] Spiroannulation of Alkyl Bromoarenes with Internal Alkynes.
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DOI: 10.1021/acs.orglett.9b00099
Abstract: Described herein is a palladium-catalyzed dearomative annulation of alkyl bromoarenes with internal alkynes. Challenges in this spiroannulation include the chemoselectivity among [2 + 2 + 1], [2 + 2 + 2], and [3 + 2]… read more here.
Keywords: heck type; internal alkynes; alkyl bromoarenes; bromoarenes internal ... See more keywords