The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111169
Abstract: Mechanisms regulating gene expression in the airway epithelium underlie its response to the environment. A network of transcription factors (TFs) and architectural proteins, modulate chromatin accessibility and recruit activating or repressive signals. Bromodomain-containing proteins function… read more here.
Keywords: network; lung epithelial; containing brd8; brd8 ... See more keywords
Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2016.203
Abstract: Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets read more here.
Keywords: therapies neuroscience; neuroscience focus; epigenetic therapies; bromodomain containing ... See more keywords
Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2023.2175317
Abstract: ABSTRACT Introduction Inflammatory bowel diseases (IBDs) are debilitating chronic inflammatory disorders with increasing prevalence worldwide. Epigenetic regulator bromodomain-containing protein 4 (BRD4) is critical in controlling gene expression of IBD-associated inflammatory cytokine networks. BRD4 as a… read more here.
Keywords: protein brd4; bromodomain containing; inflammatory bowel; inflammatory ... See more keywords
Bromodomain‐containing protein 4 inhibitor JQ1 promotes melanoma cell apoptosis by regulating mitochondrial dynamics
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.15061
Abstract: Although the role of bromodomain‐containing protein 4 (BRD4) in ovarian cancer, pancreatic cancer, lymphoma, and many other diseases is well known, its function in cutaneous melanoma is only partially understood. The results of the present… read more here.
Keywords: protein; apoptosis; jq1; bromodomain containing ... See more keywords
Abstract 2647: Bromodomain-containing protein 7 (BRD7) is a candidate tumor suppressor in breast carcinoma and prognostic biomarker
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2647
Abstract: Background Breast cancer (BC) is a multifactorial disorder in which multiple genetic and epigenetic factors changes drive tumor initiation and progression. Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family mainly localized… read more here.
Keywords: brd7; breast; expression; bromodomain containing ... See more keywords
Abstract 1108: Intestine-specific homeobox recruits p300/CBP-associated factor and bromodomain-containing protein 4 to promote epithelial-mesenchymal transition
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1108
Abstract: The epithelial-mesenchymal transition is an important process in the cancer progression, but its occurrence and the regulatory mechanism are not fully understood. Intestine specific homeobox acted both as a proto-oncogene and upstream regulator of EMT… read more here.
Keywords: bromodomain containing; containing protein; epithelial mesenchymal; specific homeobox ... See more keywords
BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circulationaha.120.047753
Abstract: Background: Gene regulatory networks control tissue homeostasis and disease progression in a cell type–specific manner. Ubiquitously expressed chromatin regulators modulate these networks, yet the ... read more here.
Keywords: bromodomain containing; homeostasis; containing protein; protein interacts ... See more keywords
Privileged Scaffolds Targeting Bromodomain-containing Protein 4.
Sign Up to like & getrecommendations! Published in 2022 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026622666220209143949
Abstract: In recent years, bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra terminal domain (BET) family, has been one of the most widely studied targets. BRD4 is a transcriptional regulation factor, which regulates… read more here.
Keywords: bromodomain containing; scaffolds targeting; privileged scaffolds; cancer ... See more keywords
A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01043
Abstract: Angiogenesis dysregulation contributes to inflammation, infections, immune disorders, and carcinogenesis. Bromodomain-containing protein 4 (BRD4) is an epigenetic reader that recognizes histone proteins and acts as a transcriptional regulator to trigger tumor growth and the inflammatory… read more here.
Keywords: inhibitor; angiogenesis; bromodomain containing; brd4 inhibitor ... See more keywords