GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
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DOI: 10.1021/acs.jmedchem.2c00662
Abstract: Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small molecules that compete with acetyllysine, and therefore bromodomains have been targets for drug discovery efforts. Highly potent and selective… read more here.
Keywords: bromodomains smarca2; smarca4; gne 064; pbrm1 ... See more keywords