Constructing multi‐enzymatic cascade reactions for selective production of 6‐bromoindirubin from tryptophan in Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28188
Abstract: 6‐Bromoindirubin (6BrIR), found in Murex sea snails, is a precursor of indirubin‐derivatives anticancer drugs. However, its synthesis remains limited due to uncharacterized biosynthetic pathways and difficulties in site‐specific bromination and oxidation at the indole ring.… read more here.
Keywords: enzymatic cascade; multi enzymatic; escherichia coli; constructing multi ... See more keywords