A shift in the IL-6/STAT3 signalling pathway imbalance towards the SHP2 pathway in severe asthma results in reduced proliferation process.
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DOI: 10.1016/j.cellsig.2017.12.001
Abstract: BACKGROUND Bronchial fibroblasts are the main structural cells responsible for extracellular matrix production and turnover in lung tissue. They play a key role in airway remodelling in asthma through different cytokines including interleukin (IL-6). OBJECTIVE… read more here.
Keywords: shp2; healthy controls; severe asthma; proliferation ... See more keywords
Extracorporeal Shock Waves Increase Markers of Cellular Proliferation in Bronchial Epithelium and in Primary Bronchial Fibroblasts of COPD Patients
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DOI: 10.1155/2020/1524716
Abstract: Chronic obstructive pulmonary disease (COPD) is due to structural changes and narrowing of small airways and parenchymal destruction (loss of the alveolar attachment as a result of pulmonary emphysema), which all lead to airflow limitation.… read more here.
Keywords: extracorporeal shock; shock waves; proliferation; bronchial fibroblasts ... See more keywords
Bcl10 Regulates Lipopolysaccharide-Induced Pro-Fibrotic Signaling in Bronchial Fibroblasts from Severe Asthma Patients
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DOI: 10.3390/biomedicines10071716
Abstract: Subepithelial fibrosis is a characteristic hallmark of airway remodeling in asthma. Current asthma medications have limited efficacy in treating fibrosis, particularly in patients with severe asthma, necessitating a deeper understanding of the fibrotic mechanisms. The… read more here.
Keywords: bronchial fibroblasts; fibrotic signaling; fibrosis; pro fibrotic ... See more keywords
PPARδ Agonist GW501516 Suppresses the TGF-β-Induced Profibrotic Response of Human Bronchial Fibroblasts from Asthmatic Patients
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DOI: 10.3390/ijms24097721
Abstract: The airway wall remodeling observed in asthma is associated with subepithelial fibrosis and enhanced activation of human bronchial fibroblasts (HBFs) in the fibroblast to myofibroblast transition (FMT), induced mainly by transforming growth factor-β (TGF-β). The… read more here.
Keywords: bronchial fibroblasts; ppar agonist; asthmatic patients; human bronchial ... See more keywords