l-Arginine promotes protein synthesis and cell growth in brown adipocyte precursor cells via the mTOR signal pathway
Sign Up to like & getrecommendations! Published in 2017 at "Amino Acids"
DOI: 10.1007/s00726-017-2399-0
Abstract: Abstractl-Arginine has been reported to enhance brown adipose tissue developments in fetal lambs of obese ewes, but the underlying mechanism is unknown. The present study tested the hypothesis that l-arginine stimulates growth and development of… read more here.
Keywords: adipocyte precursor; brown adipocyte; cell; arginine ... See more keywords
Brown Adipogenic Reprogramming Induced by a Small Molecule.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2016.12.062
Abstract: Brown adipose tissue (BAT) has attracted considerable research interest because of its therapeutic potential to treat obesity and associated metabolic diseases. Augmentation of brown fat mass and/or its function may represent an attractive strategy to… read more here.
Keywords: brown adipogenic; brown adipocyte; small molecule; induced small ... See more keywords
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.07.005
Abstract: Stimulation of brown adipose tissue (BAT) thermogenesis in humans has emerged as an attractive target to improve metabolic health. Pharmacological stimulations targeting the β3-adrenergic receptor (β3-AR), the adrenergic receptor believed to mediate BAT thermogenesis, have… read more here.
Keywords: brown adipocyte; stimulation; bat thermogenesis; adipocyte thermogenesis ... See more keywords
Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101202
Abstract: Objective Impaired circadian clocks can cause obesity, but their pathophysiological role in brown adipose tissue (BAT), a major tissue regulating energy metabolism, remains unclear. To address this issue, we investigated the effects of complete disruption… read more here.
Keywords: bmal1; brown adipocyte; bat; adipocyte specific ... See more keywords
Vitamin D–vitamin D receptor system down-regulates expression of uncoupling proteins in brown adipocyte through interaction with Hairless protein
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20194294
Abstract: Abstract Our previous study showed that feeding mice with vitamin D deficiency diet markedly alleviated high-fat-diet-induced overweight, hyperinsulinemia, and hepatic lipid accumulation. Moreover, vitamin D deficiency up-regulated the expression of uncoupling protein 3 (Ucp3) in… read more here.
Keywords: expression; hairless protein; brown adipocyte; vdr ... See more keywords
Effects of Sargaquinoic Acid in Sargassum Serratifolium on Inducing Brown Adipocyte-like Phenotype in Mouse Adipocytes In Vitro.
Sign Up to like & getrecommendations! Published in 2019 at "Planta medica"
DOI: 10.1055/a-1023-7385
Abstract: A previous study showed that the meroterpenoid-rich fraction of an ethanolic extract of Sargassum serratifolium (MES) stimulated adipose tissue browning and inhibited diet-induced obesity and metabolic syndrome. Sargaquinoic acid (SQA) is a major component in… read more here.
Keywords: brown adipocyte; sargaquinoic acid; acid sargassum; sargassum serratifolium ... See more keywords
Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1753002
Abstract: ABSTRACT Although macroautophagy/autophagy deficiency causes degenerative diseases, the deletion of essential autophagy genes in adipocytes paradoxically reduces body weight. Brown adipose tissue (BAT) plays an important role in body weight regulation and metabolic control. However,… read more here.
Keywords: brown adipocyte; dysfunction; bat dysfunction; adipose tissue ... See more keywords
2044-P: Histone Methyltransferase DOT1L Regulates Brown Adipocyte Differentiation and Thermogenesis
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DOI: 10.2337/db19-2044-p
Abstract: Brown fat has been extensively studied due to its potential in therapies against obesity. Various epigenetic regulators have been shown to modulate brown fat development and function. Here we show that histone methyltransferase DOT1L is… read more here.
Keywords: differentiation; brown adipocyte; dot1l; brown fat ... See more keywords
270-LB: Amelioration of Hepatic Insulin Resistance by Brown Adipocyte Secretion
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DOI: 10.2337/db19-270-lb
Abstract: Insulin resistance (IR) is a hallmark of T2D. In the IR state, insulin fails to inhibit hepatic glucose production yet promotes lipogenesis. Although thiazolidinediones can partially reinstate insulin sensitivity, there are concerns about long-term usage.… read more here.
Keywords: none; hepatic insulin; brown adipocyte; insulin ... See more keywords
Suppression of Brown Adipocyte Autophagy Improves Energy Metabolism by Regulating Mitochondrial Turnover
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20143520
Abstract: The high abundance of mitochondria and the expression of mitochondrial uncoupling protein 1 (UCP1) confer upon brown adipose tissue (BAT) the unique capacity to convert chemical energy into heat at the expense of ATP synthesis.… read more here.
Keywords: adipocyte autophagy; bat; brown adipocyte; energy metabolism ... See more keywords