Mammary alveolar epithelial cells convert to brown adipocytes in post‐lactating mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25858
Abstract: During pregnancy and lactation, subcutaneous white adipocytes in the mouse mammary gland transdifferentiate reversibly to milk‐secreting epithelial cells. In this study, we demonstrate by transmission electron microscopy that in the post‐lactating mammary gland interscapular multilocular… read more here.
Keywords: epithelial cells; mammary gland; brown adipocytes; mice ... See more keywords
Functional Secretion of Granulocyte Colony Stimulating Factor in Bacillus subtilis and Its Thermogenic Activity in Brown Adipocytes
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-019-0127-1
Abstract: Granulocyte colony-stimulating factor (G-CSF) is involved in generation of colonies hematopoietic cells by stimulation of bone marrow cells, resulting in the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. To express and… read more here.
Keywords: stimulating factor; csf; colony stimulating; brown adipocytes ... See more keywords
Nutritional and metabolic regulation of brown and beige adipose tissues
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-020-00745-1
Abstract: The last decade has witnessed an enormous interest of scientists and clinicians in the understanding of the biological activity of brown adipose tissue (BAT) and its role in health and disease. The importance of BAT… read more here.
Keywords: bat; beige adipose; brown beige; brown adipocytes ... See more keywords
Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.09.073
Abstract: Summary Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding… read more here.
Keywords: dynamics drives; glycogen dynamics; drives lipid; glycogen ... See more keywords
Secreted protein acidic and rich in cysteine (SPARC) regulates thermogenesis in white and brown adipocytes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110757
Abstract: SPARC, also known as osteonectin, is well known for its physiological roles in bone formation and tissue remodeling, as well as in cancer pathology; however, evidence regarding its function in adipocytes is lacking. The present… read more here.
Keywords: protein acidic; sparc; acidic rich; white brown ... See more keywords
Mechanisms of insulin resistance related to white, beige, and brown adipocytes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.12.014
Abstract: Background The diminished glucose lowering effect of insulin in obesity, called “insulin resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious maladies. Many publications on this topic have suggested numerous hypotheses on… read more here.
Keywords: white beige; brown adipocytes; resistance; insulin resistance ... See more keywords
Mitochondrial transfer in BAT
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-022-00674-7
Abstract: 0123456789();: Mitochondrial transfer between cells has been previously demonstrated to control metabolic homeostasis. Whether mitochondrial transfer occurs in brown adipose tissue (BAT) and has a role in adaptive thermogenesis was unclear. A new study in… read more here.
Keywords: bat; mitochondrial transfer; bat evs; thermogenesis ... See more keywords
Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00291-9
Abstract: The identification of brown adipose deposits in adults has led to significant interest in targeting this metabolically active tissue for treatment of obesity and diabetes. Improved methods for the direct measurement of heat production as… read more here.
Keywords: single cell; fluorescence intensity; brown adipocytes; optical visualisation ... See more keywords
Transcriptome analysis reveals brown adipogenic reprogramming in chemical compound-induced brown adipocytes converted from human dermal fibroblasts
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84611-0
Abstract: Brown adipogenesis contributes to controlling systemic energy balance by enhancing glucose and lipid consumptions. We have previously reported chemical compound-induced brown adipocytes (ciBAs) directly converted from human dermal fibroblasts using a serum-free medium. In this… read more here.
Keywords: converted human; analysis; chemical compound; brown adipocytes ... See more keywords
What activates thermogenesis when lipid droplet lipolysis is absent in brown adipocytes?
Sign Up to like & getrecommendations! Published in 2018 at "Adipocyte"
DOI: 10.1080/21623945.2018.1453769
Abstract: ABSTRACT Cold exposure activates the sympathetic nervous system. It is generally thought that this sympathetic activation induces heat production by stimulating lipolysis of cytosolic lipid droplets (LDs) in brown adipocytes. However, this concept was not… read more here.
Keywords: activates thermogenesis; lipolysis; brown adipocytes; thermogenesis lipid ... See more keywords
Brown adipocytes promote epithelial mesenchymal transition of neuroblastoma cells by inducing PPAR-γ/UCP2 expression
Sign Up to like & getrecommendations! Published in 2022 at "Adipocyte"
DOI: 10.1080/21623945.2022.2073804
Abstract: ABSTRACT Neuroblastoma (NB) is an embryonic malignant tumour of the sympathetic nervous system, and current research shows that activation of brown adipose tissue accelerates cachexia in cancer patients. However, the interaction between brown adipose tissues… read more here.
Keywords: ppar ucp2; migration cells; expression; migration ... See more keywords