Secretin Links Brown Fat to Food Intake: New Perspectives for Targeting Energy Balance in Humans
Sign Up to like & getrecommendations! Published in 2019 at "Obesity"
DOI: 10.1002/oby.22477
Abstract: In 1902, Neumann referred to the concept of Luxuskonsumption in his habilitation thesis, essentially stating that we can dissipate excess nutritional energy as heat to keep slim: “On the other hand, we also know very… read more here.
Keywords: food intake; energy balance; brown fat; energy ... See more keywords
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.10.016
Abstract: The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing… read more here.
Keywords: prandial thermogenesis; brown fat; bat; satiation ... See more keywords
Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.03.005
Abstract: Objective Increasing the amounts of functionally competent brown adipose tissue (BAT) in adult humans has the potential to restore dysfunctional metabolism and counteract obesity. In this study, we aimed to characterize the human perirenal fat… read more here.
Keywords: brown fat; bat; adipose tissue; brown adipose ... See more keywords
Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105524
Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition, by increasing hepatic low density lipoprotein (LDL) receptor (LDLR) levels, has emerged as a strategy to reduce atherosclerosis by lowering circulating very low density lipoprotein (VLDL)-cholesterol. We hypothesized… read more here.
Keywords: fat activation; inhibition; pcsk9 inhibition; atherosclerosis ... See more keywords
MicroRNA expression patterns in the brown fat of hibernating 13-lined ground squirrels.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.01.017
Abstract: The sequence diversity of microRNAs (miRNAs) allows these potent regulators of mRNA fate to bind multiple transcripts, giving them the power to inhibit diverse cellular processes. Therefore, miRNAs may regulate metabolic rate suppression (also termed… read more here.
Keywords: microrna expression; ground squirrels; expression patterns; patterns brown ... See more keywords
NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program
Sign Up to like & getrecommendations! Published in 2017 at "Nature Cell Biology"
DOI: 10.1038/ncb3590
Abstract: Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white… read more here.
Keywords: ppar; fat gene; fat specific; gene program ... See more keywords
Brown fat promotes cardiometabolic health
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-021-00508-5
Abstract: Thermogenic brown adipose tissue (BAT) is associated with a lower prevalence of cardiometabolic disease in humans, particularly in individuals who are overweight or obese, according to a retrospective cohort study. Coldactivated BAT is associated with… read more here.
Keywords: fat promotes; bat; promotes cardiometabolic; cardiometabolic health ... See more keywords
Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvz253
Abstract: Abstract Aims Brown fat activation accelerates the uptake of cholesterol-enriched remnants by the liver and thereby lowers plasma cholesterol, consequently protecting against atherosclerosis development. Hepatic cholesterol is then converted into bile acids (BAs) that are… read more here.
Keywords: atherosclerosis development; fat activation; cholesterol; brown fat ... See more keywords
Atypically Intense Pharmacologically Induced Brown Fat Activation on FDG PET/CT
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000004520
Abstract: Abstract Brown fat activation with increased radiotracer localization on FDG PET/CT studies is a well-known phenomenon. Activated brown adipose tissue (BAT) is usually seen in the supraclavicular region, but also in paraspinal and rarely in… read more here.
Keywords: atypically intense; fdg pet; fat activation; brown fat ... See more keywords
Keeping brown fat brown.
Sign Up to like & getrecommendations! Published in 2022 at "Science signaling"
DOI: 10.1126/scisignal.adg3025
Abstract: The multilocular phenotype of brown adipose tissue is determined by an ER-lipid droplet anchoring protein. read more here.
Keywords: keeping brown; fat brown; brown fat;
NFIA Colocalizes with PPARgamma and Activates the Cell-Type–Specific Enhancers to Control the Brown Fat Gene Program
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-270-or
Abstract: Brown fat dissipates energy as heat by means of the uncoupling protein-1 (UCP1) on the mitochondrial inner membrane. Brown fat activity is inversely correlated with body mass index in humans, and pilot studies have shown… read more here.
Keywords: fat specific; ltd; novo nordisk; pharmaceutical ltd ... See more keywords