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   Articles with "brown fat" as a keyword



Secretin Links Brown Fat to Food Intake: New Perspectives for Targeting Energy Balance in Humans

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recommendations! Published in 2019 at "Obesity"

DOI: 10.1002/oby.22477

Abstract: In 1902, Neumann referred to the concept of Luxuskonsumption in his habilitation thesis, essentially stating that we can dissipate excess nutritional energy as heat to keep slim: “On the other hand, we also know very… read more here.

Keywords: food intake; energy balance; brown fat; energy ... See more keywords

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

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recommendations! Published in 2018 at "Cell"

DOI: 10.1016/j.cell.2018.10.016

Abstract: The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing… read more here.

Keywords: prandial thermogenesis; brown fat; bat; satiation ... See more keywords

Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells

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recommendations! Published in 2019 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2019.03.005

Abstract: Objective Increasing the amounts of functionally competent brown adipose tissue (BAT) in adult humans has the potential to restore dysfunctional metabolism and counteract obesity. In this study, we aimed to characterize the human perirenal fat… read more here.

Keywords: brown fat; bat; adipose tissue; brown adipose ... See more keywords
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Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice.

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recommendations! Published in 2021 at "Pharmacological research"

DOI: 10.1016/j.phrs.2021.105524

Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition, by increasing hepatic low density lipoprotein (LDL) receptor (LDLR) levels, has emerged as a strategy to reduce atherosclerosis by lowering circulating very low density lipoprotein (VLDL)-cholesterol. We hypothesized… read more here.

Keywords: fat activation; inhibition; pcsk9 inhibition; atherosclerosis ... See more keywords

MicroRNA expression patterns in the brown fat of hibernating 13-lined ground squirrels.

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recommendations! Published in 2021 at "Genomics"

DOI: 10.1016/j.ygeno.2021.01.017

Abstract: The sequence diversity of microRNAs (miRNAs) allows these potent regulators of mRNA fate to bind multiple transcripts, giving them the power to inhibit diverse cellular processes. Therefore, miRNAs may regulate metabolic rate suppression (also termed… read more here.

Keywords: microrna expression; ground squirrels; expression patterns; patterns brown ... See more keywords

NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

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recommendations! Published in 2017 at "Nature Cell Biology"

DOI: 10.1038/ncb3590

Abstract: Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white… read more here.

Keywords: ppar; fat gene; fat specific; gene program ... See more keywords

SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice

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recommendations! Published in 2024 at "Cell Death and Differentiation"

DOI: 10.1038/s41418-024-01397-0

Abstract: Brown adipose tissue (BAT) is critical for non-shivering thermogenesis making it a promising therapeutic strategy to combat obesity and metabolic disease. However, the regulatory mechanisms underlying brown fat formation remain incompletely understood. Here, we found… read more here.

Keywords: brown fat; bat; sox4; ebf2 ... See more keywords
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Brown fat promotes cardiometabolic health

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recommendations! Published in 2021 at "Nature Reviews Cardiology"

DOI: 10.1038/s41569-021-00508-5

Abstract: Thermogenic brown adipose tissue (BAT) is associated with a lower prevalence of cardiometabolic disease in humans, particularly in individuals who are overweight or obese, according to a retrospective cohort study. Coldactivated BAT is associated with… read more here.

Keywords: fat promotes; bat; promotes cardiometabolic; cardiometabolic health ... See more keywords

E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat

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recommendations! Published in 2025 at "EMBO Reports"

DOI: 10.1038/s44319-024-00337-w

Abstract: Thermogenic fat, including brown and beige fat, dissipates heat via thermogenesis and enhances energy expenditure. Thus, its activation represents a therapeutic strategy to combat obesity. Here, we demonstrate that levels of F-box and WD repeat… read more here.

Keywords: fbxw7 depletion; fat expansion; brown fat; fat ... See more keywords

Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development

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recommendations! Published in 2019 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvz253

Abstract: Abstract Aims Brown fat activation accelerates the uptake of cholesterol-enriched remnants by the liver and thereby lowers plasma cholesterol, consequently protecting against atherosclerosis development. Hepatic cholesterol is then converted into bile acids (BAs) that are… read more here.

Keywords: atherosclerosis development; fat activation; cholesterol; brown fat ... See more keywords

Atypically Intense Pharmacologically Induced Brown Fat Activation on FDG PET/CT

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recommendations! Published in 2023 at "Clinical Nuclear Medicine"

DOI: 10.1097/rlu.0000000000004520

Abstract: Abstract Brown fat activation with increased radiotracer localization on FDG PET/CT studies is a well-known phenomenon. Activated brown adipose tissue (BAT) is usually seen in the supraclavicular region, but also in paraspinal and rarely in… read more here.

Keywords: atypically intense; fdg pet; fat activation; brown fat ... See more keywords