Solution structure of TbUfm1 from Trypanosoma brucei and its binding to TbUba5.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2020.107580
Abstract: Ubiquitin-like proteins are conserved in eukaryotes and involved in numerous cellular processes. Ufm1 is proved to play important roles in endoplasmic reticulum homeostasis, vesicle transportation and embryonic development. Enzyme cascade of Ufm1 is similar to… read more here.
Keywords: tbufm1; brucei; solution structure; tbufm1 trypanosoma ... See more keywords
In vitro effects and mechanisms of action of Bidens pilosa in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2021.08.008
Abstract: Abstract Background and aim African trypanosomiasis poses serious health and economic concerns to humans and livestock in several sub-Saharan African countries. The aim of the present study was to identify the antitrypanosomal compounds from B. pilosa… read more here.
Keywords: vitro effects; effects mechanisms; mechanisms action; brucei ... See more keywords
Induction of apoptosis in Trypanosoma brucei following endocytosis of ultra-small noble metal nanoclusters
Sign Up to like & getrecommendations! Published in 2021 at "Nano Today"
DOI: 10.1016/j.nantod.2021.101122
Abstract: Abstract Trypanosoma brucei, the causative agent of African trypanosomiasis, is a unicellular protozoan with an intricate life cycle involving an insect vector and mammalian hosts. Trypanosomiasis remains a threat to the health of human beings… read more here.
Keywords: endocytosis; trypanosoma brucei; metal nanoclusters; brucei ... See more keywords
Assessment of selected medicinal plants indigenous to West Africa for antiprotozoal activity
Sign Up to like & getrecommendations! Published in 2017 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2017.08.002
Abstract: Abstract Ethnopharmacological relevance The disease burden of protozoal infections is enormous in West Africa and other developing regions of the world. Malaria is one of the most important parasitic disease in tropical areas caused by… read more here.
Keywords: west africa; brucei; medicinal plants; chloroform ... See more keywords
Azithromycin and Diminazene Aceturate Combination Therapy in Experimental Multidrug-resistant Trypanosoma brucei brucei Infection in Albino Rats.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary parasitology"
DOI: 10.1016/j.vetpar.2020.109138
Abstract: Azithromycin and diminazene aceturate combination therapy in experimental multidrug-resistant Trypanosoma brucei brucei infection in albino rats was evaluated. A total of forty-five female albino rats were used. These rats were randomly assigned to nine groups… read more here.
Keywords: combination; diminazene aceturate; group; brucei ... See more keywords
APOLs with low pH dependence can kill all African trypanosomes
Sign Up to like & getrecommendations! Published in 2017 at "Nature microbiology"
DOI: 10.1038/s41564-017-0034-1
Abstract: The primate-specific serum protein apolipoprotein L1 (APOL1) is the only secreted member of a family of cell death promoting proteins1–4. APOL1 kills the bloodstream parasite Trypanosoma brucei brucei, but not the human sleeping sickness agents… read more here.
Keywords: dependence; apols low; brucei; african trypanosomes ... See more keywords
The 27 kDa Trypanosoma brucei Pentatricopeptide Repeat Protein is a G-tract Specific RNA Binding Protein
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34377-9
Abstract: Pentatricopeptide repeat (PPR) proteins, a helical repeat family of organellar RNA binding proteins, play essential roles in post-transcriptional RNA processing. In Trypanosoma brucei, an expanded family of PPR proteins localize to the parasite’s single mitochondrion,… read more here.
Keywords: protein; rna; rna binding; brucei ... See more keywords
Emerging compounds and therapeutic strategies to treat infections from Trypanosoma brucei: an overhaul of the last 5-years patents
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2023.2193328
Abstract: ABSTRACT Introduction Human African Trypanosomiasis is a neglected disease caused by infection from parasites belonging to the Trypanosoma brucei species. Only six drugs are currently available and employed depending on the stage of the infection:… read more here.
Keywords: trypanosoma brucei; therapeutic strategies; compounds therapeutic; patents emerging ... See more keywords
In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1042
Abstract: Abstract Telomerase is a unique ribonucleoprotein (RNP) reverse transcriptase that utilizes its cognate RNA molecule as a template for telomere DNA repeat synthesis. Telomerase contains the reverse transcriptase protein, TERT and the template RNA, TR,… read more here.
Keywords: vivo; telomerase; brucei; telomerase rna ... See more keywords
Trypanosoma brucei histones are heavily modified with combinatorial post-translational modifications and mark Pol II transcription start regions with hyperacetylated H2A
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac759
Abstract: Abstract Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and display some unusual genomic and epigenetic properties that provide valuable insight into the early processes employed by eukaryotic ancestors to regulate… read more here.
Keywords: trypanosoma brucei; translational modifications; post translational; brucei histones ... See more keywords
Phosphatidylserine synthase 2 and phosphatidylserine decarboxylase are essential for aminophospholipid synthesis in T rypanosoma brucei
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13637
Abstract: Phosphatidylethanolamine (PE) and phosphatidylserine (PS) are ubiquitously expressed and metabolically interconnected glycerophospholipids in eukaryotes and prokaryotes. In Trypanosoma brucei, PE synthesis has been shown to occur mainly via the Kennedy pathway, one of the three… read more here.
Keywords: aminophospholipid synthesis; decarboxylase; synthase; brucei ... See more keywords