C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
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DOI: 10.1016/j.ejmech.2021.113798
Abstract: Some pathogens, including parasites of the genus Trypanosoma causing Human and Animal African Trypanosomiases, cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation. Thus, their… read more here.
Keywords: nucleoside phosphonates; brucei adenine; trypanosoma brucei; adenosine monophosphate ... See more keywords